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850468P

Avanti

18:0-18:2 PC

1-stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine, powder

Sinônimo(s):

1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine; PC(18:0/18:2(9Z,12Z))

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About This Item

Fórmula empírica (Notação de Hill):
C44H84NO8P
Número CAS:
27098-24-4
Peso molecular:
786.11
Número MDL:
MFCD00674330
Código UNSPSC:
51191904
NACRES:
NA.25
Preço e disponibilidade não estão disponíveis no momento.

Ensaio

>99% (TLC)

Formulário

powder

embalagem

pkg of 2 × 100 mg (850468P-200mg)
pkg of 1 × 25 mg (850468P-25mg)

fabricante/nome comercial

Avanti Research™ - A Croda Brand 850468P

tipo de lipídio

phospholipids
cardiolipins

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O

InChI

1S/C44H84NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h15,17,21,23,42H,6-14,16,18-20,22,24-41H2,1-5H3/b17-15-,23-21-/t42-/m1/s1

chave InChI

FORFDCPQKJHEBF-VPUSDGANSA-N

Descrição geral

18:0-18:2 phosphatidylcholine (PC) has a saturated fatty acid at the sn-1 position, unsaturated fatty acid at the sn-2 position and phosphate-containing polar group at the sn-3 position.[1] PC is a zwitterionic phospholipid. PC is synthesized by Kennedy pathway from choline.[2]

Aplicação

18:0-18:2 PC is suitable for use:
  • in the preparation of large unilamellar vesicles[1]
  • in the preparation of liposomes[3]
  • to prepare oxidised phospholipid by 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH) for multiple reaction monitoring (MRM) analysis[4]

Ações bioquímicas/fisiológicas

Phosphatidylcholine is one of the major glycerophospholipids of the eukaryotic membranes. It is essential for maintaining the structure and functions of the membrane. PC is the substrate for sphingomyelin synthesis. PC is the precursor for various second messenger like phosphatidic acid, lysophosphatidic acid, diacylglycerol.[2]

Embalagem

5 mL Clear Glass Sealed Ampule (850468P-200mg)
5 mL Clear Glass Sealed Ampule (850468P-25mg)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Código de classe de armazenamento

11 - Combustible Solids

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Certificados de análise (COA)

Lot/Batch Number

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Development of oxidized phosphatidylcholine isomer profiling method using supercritical fluid chromatography/tandem mass spectrometry
Uchikata T, et al.
Journal of Chromatography A, 1250(2), 205-211 (2012)
Z Djuric et al.
Journal of biochemical and molecular toxicology, 15(2), 114-119 (2001-04-03)
Lipid and DNA oxidation catalyzed by iron(II) were compared in HEPES and phosphate buffers. Lipid peroxidation was examined in a sensitive liposome system constructed with a fluorescent probe that allowed us to examine the effects of both low and high
A Arora et al.
Archives of biochemistry and biophysics, 373(1), 102-109 (2000-01-06)
The polyphenolic structures of flavonoids and isoflavonoids confer them with the ability to scavenge free radicals and to chelate transition metals, a basis for their potent antioxidant abilities. Another possible contributory mechanism toward their antioxidant activities is their ability to
The Kennedy pathway?de novo synthesis of phosphatidylethanolamine and phosphatidylcholine
Gibellini F and Smith TK
IUBMB Life, 62(6), 414-428 (2010)
Wenbo Cao et al.
Analytical chemistry, 90(17), 10286-10292 (2018-08-11)
The presence of carbon-carbon double bonds (C═Cs) in unsaturated phospholipids is closely related to lipid conformations and physiochemical activities. Previously, we have demonstrated that epoxidation reaction facilitated by low-temperature plasma (LTP) enabled the structural analysis of unsaturated fatty acids (FAs).

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