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Documentos Principais

810128C

Avanti

12:0 Lyso NBD PC

Avanti Research™ - A Croda Brand 810128C

Sinônimo(s):

1-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-2-hydroxy-sn-glycero-3-phosphocholine

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About This Item

Fórmula empírica (Notação de Hill):
C26H44N5O10P
Número CAS:
1246303-00-3
Peso molecular:
617.63
Código UNSPSC:
12352211
NACRES:
NA.25
Preço e disponibilidade não estão disponíveis no momento.

Ensaio

>99% (LPC; may contain up to 10% of the 2-LPC isomer, TLC)

Formulário

liquid

embalagem

pkg of 1 × 1 mL (810128C-1mg)
pkg of 5 × 1 mL (810128C-5mg)

fabricante/nome comercial

Avanti Research™ - A Croda Brand 810128C

concentração

1 mg/mL (810128C-1mg)
1 mg/mL (810128C-5mg)

tipo de lipídio

fluorescent lipids

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

Aplicação

12:0 Lyso NBD PC may be used as a substrate to measure the enzymatic activity of recombinant human lysophosphatidylcholine acyltransferase 3 (rhLPCAT3)[1] and to study the function of lysophosphatidic acid (LPA) as an inhibitor in the autotaxin (ATX) catalysis.[2]

Embalagem

5 mL Clear Glass Sealed Ampule (810128C-1mg)
5 mL Clear Glass Sealed Ampule (810128C-5mg)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictogramas

Skull and crossbonesHealth hazard
GHS06,GHS08

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Órgãos-alvo

Central nervous system

Código de classe de armazenamento

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

does not flash

Ponto de fulgor (°C)

does not flash

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Certificados de análise (COA)

Lot/Batch Number

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Fernando Salgado-Polo et al.
The Journal of biological chemistry, 293(37), 14312-14327 (2018-07-22)
Autotaxin (ATX) is a secreted glycoprotein and the only member of the ectonucleotide pyrophosphatase/phosphodiesterase family that converts lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA). LPA controls key responses, such as cell migration, proliferation, and survival, implicating ATX-LPA signaling in various (patho)physiological
Lauren P Saunders et al.
The Journal of biological chemistry, 286(34), 30130-30141 (2011-07-02)
Autotaxin (ATX) is a secreted lysophospholipase D that hydrolyzes lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA), initiating signaling cascades leading to cancer metastasis, wound healing, and angiogenesis. Knowledge of the pathway and kinetics of LPA synthesis by ATX is critical for
Xinming Du et al.
FEBS open bio, 9(10), 1734-1743 (2019-08-04)
Lysophosphatidylcholine acyltransferase 3 (LPCAT3) is an important enzyme in phospholipid remodeling, a process that influences the biophysical properties of cell membranes and thus cell function. Multiple lines of evidence suggest that LPCAT3 is involved in several diseases, including atherosclerosis, non-alcoholic
Stephen M Baumler et al.
Langmuir : the ACS journal of surfaces and colloids, 33(12), 2986-2992 (2017-03-08)
The translational diffusion dynamics of the zwitterionic lipid 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) at a planar phosphorylated support surface containing metal ions (Mg2+, Ca2+, Ba2+, Ni2+, Zn2+, Cd2+, Zr4+) was investigated using X-ray photoelectron spectroscopy (XPS) and fluorescence recovery after photobleaching (FRAP). Fluorescence

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Critical Micelle Concentrations (CMCs) - Avanti® Polar Lipids

The critical micelle concentration (CMC) can be approximately defined as the lipid monomer concentration at which appreciable amounts (>5% of total) of micellar aggregates first begin to appear in the equilibrium: nM1<=>Mn

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