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710341C

Avanti

16:0-18:1 Cardiolipin

Avanti Research™ - A Croda Brand

Sinônimo(s):

1′,3′-bis[1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho]-glycerol, sodium salt

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About This Item

Fórmula empírica (Notação de Hill):
C77H144Na2O17P2
Número CAS:
2260669-35-8
Peso molecular:
1449.88
Código UNSPSC:
51191904
NACRES:
NA.25
Preço e disponibilidade não estão disponíveis no momento.

Ensaio

>99% (TLC)

Formulário

chloroform solution

embalagem

pkg of 1 × 2.5 mL (710341C-25MG)

fabricante/nome comercial

Avanti Research™ - A Croda Brand

concentração

10 mg/mL in chloroform (710341C-25MG)

tipo de lipídio

cardiolipins
phospholipids

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

O=P([O-])(OC[C@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)OCC([H])(O)COP([O-])(OC[C@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)=O.[Na+].[Na+]

InChI

1S/C77H146O17P2.2Na/c1-5-9-13-17-21-25-29-33-35-39-43-47-51-55-59-63-76(81)93-72(67-87-74(79)61-57-53-49-45-41-37-31-27-23-19-15-11-7-3)69-91-95(83,84)89-65-71(78)66-90-96(85,86)92-70-73(68-88-75(80)62-58-54-50-46-42-38-32-28-24-20-16-12-8-4)94-77(82)64-6

chave InChI

QTGHEOQPDHDHHT-IPKHONCISA-L

Descrição geral

Cardiolipin is a 1,3-diphosphatidyl-sn-glycerol, a homodimeric phospholipid with four fatty acids. Cardiolipin is unique because of its atypical fatty acid composition. It is present in the mitochondrial membrane.[1] CL species are complex in structure and several permutations exists due to variations in the chain length, degree of unsaturation, as well as combinations of four fatty acid substituents.[2]

Ações bioquímicas/fisiológicas

Cardiolipin is a specific marker of mitochondria and is essential for multiple roles like energy transformation, apoptosis, and membrane integrity.[1] 16:0-18:1 is a nascent cardiolipin acts as a precursor for the synthesis of tetralinoleoyl cardiolipin (TLCL).[3]

Embalagem

5 mL Amber Glass Screw Cap Vial (710341C-25MG)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC

geralmente comprado junto com este produto

Nº do produto
Descrição
Preços

Pictogramas

Skull and crossbonesHealth hazard
GHS06,GHS08

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

Órgãos-alvo

Central nervous system, Liver,Kidney

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

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Certificados de análise (COA)

Lot/Batch Number

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1,1′-Dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate BioReagent, suitable for fluorescence, ≥98.0% (TLC)

Sigma-Aldrich

42364

1,1′-Dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate

Cardiolipin solution from bovine heart 4.7-5.3 mg/mL in ethanol, ≥97% (TLC), Suitable for manufacturing of diagnostic kits and reagents

Sigma-Aldrich

SRE0029

Cardiolipin solution from bovine heart

16:0-18:1 PE Avanti Research™ - A Croda Brand

Avanti

850757P

16:0-18:1 PE

Molecular symmetry in mitochondrial cardiolipins
Schlame M, et al.
Chemistry and Physics of Lipids, 138(1-2), 38-49 (2005)
Clare L Laut et al.
mBio, 11(2) (2020-04-03)
Bacillus anthracis is a spore-forming bacterium that causes devastating infections and has been used as a bioterror agent. This pathogen can survive hostile environments through the signaling activity of two-component systems, which couple environmental sensing with transcriptional activation to initiate
The phospholipase iPLA2gamma is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling
Liu GY, et al.
The Journal of Biological Chemistry, 292(25), 10672-10684 (2017)
Characterization of cardiolipin as the sodiated ions by positive-ion electrospray ionization with multiple stage quadrupole ion-trap mass spectrometry
Hsu FF and Turk J
Journal of the American Society For Mass Spectrometry, 17(8), 1146-1157 (2006)
Lavanya Visvabharathy et al.
PLoS pathogens, 16(4), e1008443-e1008443 (2020-04-29)
Staphylococcus aureus (SA) is the causative agent of both skin/soft tissue infections as well as invasive bloodstream infections. Though vaccines have been developed to target both humoral and T cell-mediated immune responses against SA, they have largely failed due to
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