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QBD11026

Sigma-Aldrich

m-dPEG®24-DSPE

>95% (HPLC)

Sinônimo(s):

m-PEG24-DSPE, DSPE-PEG24-OMe, mPEG-DSPE, mPEG1000-DSPE, mPEG24-DSPE

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About This Item

Fórmula empírica (Notação de Hill):
C91H180NO33P
Peso molecular:
1847.36
Número MDL:
MFCD28118972
Código UNSPSC:
12352200

Ensaio

>95% (HPLC)

Formulário

solid or viscous liquid

adequação da reação

reaction type: Pegylations

arquitetura do polímero

shape: linear
functionality: monofunctional

Condições de expedição

ambient

temperatura de armazenamento

−20°C

Características e benefícios

m-dPEG24-DSPE is the lipid 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) modified with a methoxy-terminated, single molecular weight, discrete polyethylene glycol (dPEG). This product is designed to protect liposomes and micelles from opsonization and elimination by the reticuloendothelial system (RES). The hydrophilic head is 74 atoms (86.2 Å) long and has a molecular weight of approximately 1100 Daltons. The dPEG24 is a monodisperse equivalent of the polymeric PEG1000.

Informações legais

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number

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Gavin T Noble et al.
Trends in biotechnology, 32(1), 32-45 (2013-11-12)
Nanomedicine, particularly liposomal drug delivery, has expanded considerably over the past few decades, and several liposomal drugs are already providing improved clinical outcomes. Liposomes have now progressed beyond simple, inert drug carriers and can be designed to be highly responsive
Jared F Stefanick et al.
ACS nano, 7(4), 2935-2947 (2013-02-21)
PEGylated liposomes are attractive pharmaceutical nanocarriers; however, literature reports of ligand-targeted nanoparticles have not consistently shown successful results. Here, we employed a multifaceted synthetic strategy to prepare peptide-targeted liposomal nanoparticles with high purity, reproducibility, and precisely controlled stoichiometry of functionalities
Jared F Stefanick et al.
ACS nano, 7(9), 8115-8127 (2013-09-06)
Ligand-targeted nanoparticles are emerging drug delivery vehicles for cancer therapy. Here, we demonstrate that the cellular uptake of peptide-targeted liposomes and micelles can be significantly enhanced by increasing the hydrophilicity of the targeting peptide sequence while simultaneously optimizing the EG

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