QBD10552

MAL-dPEG^®₈-TFP ester

• Sinônimo(s): Polyethylene glycol
• Fórmula empírica (Notação de Hill): C₃₂H₄₄F₄N₂O₁₃
• Peso molecular: 740.69
• Número MDL: MFCD28505514
• Código UNSPSC: 12352108
• ID de substância PubChem: 329823941
• NACRES: NA.22

Propriedades

• Ensaio: >90%
• forma: solid or viscous liquid
• adequação da reação: reactivity: thiol reactive; reagent type: cross-linking reagent; reactivity: amine reactive
• grupo funcional: ester; maleimide
• arquitetura do polímero: shape: linear; functionality: heterobifunctional
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: O=C(OC1=C(F)C(F)=CC(F)=C1F)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN2C(C=CC2=O)=O)=O

Descrição

Características e benefícios

MAL-dPEG^®₈-TFP ester is a heterobifunctional, linear crosslinking reagent containing a maleimide group on one end of the single molecular weight dPEG^® spacer arm and an amine-reactive active ester on the other end. The maleimide group reacts readily and specifically with free sulfhydryl groups in aqueous media at pH 6.5-7.5. The 2,3,5,6-tetrafluorophenyl (TFP) ester is used widely in reactions with primary amines. The TFP-amine reactions can be carried out in aqueous or organic solvent. The dPEG^® spacer is hydrophilic and non-immunogenic. Because it is a single molecular weight product, it gives the user precise spatial control. The dPEG^® spacer also improves water solubility, decreases immunogenicity, and increases the hydrodynamic volume of the conjugate. The increased hydrodynamic volume results in longer serum half-life in vivo.

Informações legais

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable