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Documentos

A76907

Sigma-Aldrich

6-Thioguanine

98%

Sinônimo(s):

2-Amino-6-mercaptopurine, 2-Amino-6-purinethiol

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About This Item

Fórmula empírica (Notação de Hill):
C5H5N5S
Número CAS:
154-42-7
Peso molecular:
167.19
Beilstein:
157765
Número CE:
205-827-2
Número MDL:
MFCD00233553
Código UNSPSC:
12352200

Ensaio

98%

pf

≥300 °C (lit.)

cadeia de caracteres SMILES

NC1=Nc2nc[nH]c2C(=S)N1

InChI

1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)

chave InChI

WYWHKKSPHMUBEB-UHFFFAOYSA-N

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Ações bioquímicas/fisiológicas

Ribosylated and phosphorylated by the same pathway as natural purine bases; as the nucleotide, inhibits a variety of cellular processes involved in nucleic acid synthesis. Has a long history as an effective treatment of leukemia.

substituído por

Nº do produto
Descrição
Preços

A4882

6-Thioguanine, ≥98%

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H301

Declarações de precaução

P301 + P310

Classificações de perigo

Acute Tox. 3 Oral

Código de classe de armazenamento

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Elif Gürsoy et al.
European journal of medicinal chemistry, 42(3), 320-326 (2006-12-06)
A series of arylidenehydrazides (3a-3i) were synthesized from [6-(4-bromophenyl)imidazo[2,1-b]thiazol-3-yl]acetic acid hydrazide. The structures of new compounds were determined by analytical and spectral (IR, (1)H NMR, (13)C NMR, EIMS) methods. The synthesized compounds (3a-3i) were evaluated in the National Cancer Institute's
Jignesh M Doshi et al.
Journal of medicinal chemistry, 49(26), 7731-7739 (2006-12-22)
The structure-activity relationship studies of ethyl 2-amino-6-cyclopentyl-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (1, HA 14-1), an antagonist of the antiapoptotic Bcl-2 proteins, are reported. A series of analogues of 1 with varied functional groups at the 6-position of the chromene ring were synthesized. These candidates
Gustavo H B Maegawa et al.
The Journal of biological chemistry, 282(12), 9150-9161 (2007-01-24)
Late-onset GM2 gangliosidosis is composed of two related, autosomal recessive, neurodegenerative diseases, both resulting from deficiency of lysosomal, heterodimeric beta-hexosaminidase A (Hex A, alphabeta). Pharmacological chaperones (PC) are small molecules that can stabilize the conformation of a mutant protein, allowing
Alex M Aronov et al.
Journal of medicinal chemistry, 51(5), 1214-1222 (2008-02-22)
Small molecule protein kinase inhibitors are widely employed as biological reagents and as leads in the design of drugs for a variety of diseases. We investigated the phenomenon of kinase-likeness, i.e., the propensity of ligands to inhibit protein kinases, in
Lucie Brulíková et al.
European journal of medicinal chemistry, 45(9), 3588-3594 (2010-07-08)
A series of uridine analogues modified at the 5-position with the 5-[alkoxy-(4-nitrophenyl)-methyl] moiety was synthesized. Nucleosides were formed as a mixture of two diastereoisomers, which were separated and tested for their cytotoxic activity in vitro against different cancer cell lines
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