938882
NanoFabTx Polymers for Microneedles
Hyaluronic acid sodium salt
Sinônimo(s):
Hyaluronic acid sodium salt
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About This Item
Preço e disponibilidade não estão disponíveis no momento.
Produtos recomendados
Nível de qualidade
Ensaio
≥90%
peso molecular
100-150 kDa
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
O[C@H]1[C@H](O[C@@H]2O[C@H](C(O[Na])=O)[C@@H](OC)[C@H](O)[C@H]2O)[C@@H](NC(C)=O)[C@H](C)O[C@@H]1CO
Aplicação
NanoFabTx™ Polymers for Microneedles are carefully selected polymers that can be used to formulate microneedle patches. Microneedles are tiny projections of needles approximately 400-800um in length arranged in a small 1cm x 1cm patch. Microneedles are composed of blends of synthetic or natural polymers at suitable concentrations. Sodium hyaluronic acid (HA) is the derivate of a natural polymer and is a natural polysaccharide. It is a water-soluble polymer and is available in different molecular weights. The formation of the microneedles depends on the molecular weight and concentration of HA.
The NanoFabTx™ Polymers for Microneedles can be used with the microneedle templates to formulate microneedle that can be used for several applications, such as delivering various therapeutic molecules and vaccine antigens via the skin. The selected polymer will enable users to:
1)save time in selecting the polymer and provide a starting point to formulate microneedles by avoiding lengthy trial-and-error optimization.
2)formulate microneedles for various drug delivery applications.
The NanoFabTx™ Polymers for Microneedles can be used with the microneedle templates to formulate microneedle that can be used for several applications, such as delivering various therapeutic molecules and vaccine antigens via the skin. The selected polymer will enable users to:
1)save time in selecting the polymer and provide a starting point to formulate microneedles by avoiding lengthy trial-and-error optimization.
2)formulate microneedles for various drug delivery applications.
Informações legais
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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A dual-delivery platform for vaccination using antigen-loaded nanoparticles in dissolving microneedles
Gomes K B, et al.
International Journal of Pharmaceutics, 613, 121393-121393 (2022)
Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development
Larra?eta E, et al.
Materials Science & Engineering. R, Reports : A Review Journal, 104, 1-32 (2016)
Keegan Braz Gomes et al.
International journal of pharmaceutics, 613, 121393-121393 (2021-12-21)
Effective vaccines delivered via painless methods would revolutionize the way people approach vaccinations. This study focused on the development of fast-dissolving microneedles (MNs) to deliver antigen-loaded sustained release polymeric nanoparticles (NPs), achieving a dual-delivery platform for vaccination through the skin.
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