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930741

Sigma-Aldrich

Poly(oligoethylene glycol methacrylate)

Sinônimo(s):

POEGMA, Poly(oligo(ethylene glycol)methacrylate)

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About This Item

Fórmula linear:
C6H8NO2[C4H5O2(C2H4O)x]nOH
Código UNSPSC:
12352104
NACRES:
NA.21
Preço e disponibilidade não estão disponíveis no momento.

Formulário

liquid

Nível de qualidade

100

peso molecular

80,000-130,000

cor

colorless

temperatura de armazenamento

−20°C

Descrição geral

Poly(oligo(ethylene glycol) methacrylate) (POEGMA) is a family of polymers consisting of a hydrophobic methacrylate backbone and hydrophilic ethylene oxide (EO) side groups with highly branched architecture. The highly branched architecture with a high density of oligo EO moities enhances the solubility of the polymer in water.

Aplicação

  • Drug delivery- enhances the stability and delivery of siRNA and eliminates PEG antigenicity
  • Biosensor coatings- provides an anti-fouling surface
  • Stimuli-responsive hydrogels for tissue engineering, drug delivery, and other biomedical applications
Poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA) is a family of polymers consisting of a hydrophobic methacrylate backbone and hydrophilic ethylene oxide (EO) side groups with highly branched architecture[1] . The side chain EO segments enhance the solubility of the polymer in water [2], exhibiting many interesting properties such as non-fouling [3], stealth, anti-PEG antibodies [4] & thermo-responsive [5] behaviors.

Características e benefícios

  • Highly branched architecture and high density of oligo ethylene oxide moieties
  • Water soluble
  • Nonfouling and thermo-responsive behaviors
  • Viable alternative to PEG in biological and biomaterial applications

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
MKCS2288

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In Pursuit of Zero 2.0: Recent Developments in Nonfouling Polymer Brushes for Immunoassays
Heggestad J., et al.
Advanced Materials, 32 (2020)
Fei Xu et al.
ACS biomaterials science & engineering, 7(9), 4258-4268 (2021-02-12)
Reactive electrospinning is demonstrated as a viable method to create fast-responsive and degradable macroporous thermoresponsive hydrogels based on poly(oligoethylene glycol methacrylate) (POEGMA). Hydrazide- and aldehyde-functionalized POEGMA precursor polymers were coelectrospun to create hydrazone cross-linked nanostructured hydrogels in a single processing
Rafael Pires-Oliveira et al.
Langmuir : the ACS journal of surfaces and colloids, 36(49), 15018-15029 (2020-12-05)
Understanding of the temperature-induced phase transition of poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA) random copolymers with varied composition remains largely incomplete. Upon heating they can form either macroscopically phase-separated aggregates or micelles. We examined the effect of polymer architecture by
Yizhi Qi et al.
Nature biomedical engineering, 1 (2016-01-01)
The delivery of therapeutic peptides and proteins is often challenged by a short half-life, and thus the need for frequent injections that limit efficacy, reduce patient compliance and increase treatment cost. Here, we demonstrate that a single subcutaneous injection of
(Co)polymers of oligo(ethylene glycol) methacrylates?temperature-induced aggregation in aqueous solution.
Trzebicka B, et al.
Journal of Polymer Science Part A: Polymer Chemistry, 51, 614?623-614?623 (2013)

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