930210

N-(2,5-Dichlorobenzoyl)glycyl-L-leucine

≥95.0%

• Sinônimo(s): (2S)-2-{2-[(2,5-Dichlorophenyl)formamido]acetamido}-4-methylpentanoic acid, CANDDY_MLN Tag
• Fórmula empírica (Notação de Hill): C₁₅H₁₈Cl₂N₂O₄
• Número CAS: 1824976-81-9
• Peso molecular: 361.22
• Código UNSPSC: 12352209
• NACRES: NA.22

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95.0%
• Formulário: powder
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: ClC1=CC=C(Cl)C(C(NCC(N[C@H](C(O)=O)CC(C)C)=O)=O)=C1
• InChI: 1S/C15H18Cl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12H,5,7H2,1-2H3,(H,18,21)(H,19,20)(H,22,23)/t12-/m0/s1
• chave InChI: DNIFDGIEBFRALC-LBPRGKRZSA-N

Descrição

Aplicação

CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) employs a bispecific molecule (target interactor + linker + CANDDY_MLN) that degrades protein by direct recruitment to the proteasome. Shown to selectively and dose-dependently degrade KRAS G12D/V and MDM2 proteins and suppress their signaling without non-specific cytotoxic effects.

CANDDY, a protein-slaying approach, occurs without ubiquitination and bypasses the need for an E3 ligase. Has the potential to overcome the current limitations of proteolysis and to expand the application scope of degraders.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable