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Merck
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Documentos Principais

918741

Sigma-Aldrich

TissueFab® bioink 

(Gel)ma -VIS/405nm, low endotoxin

Sinônimo(s):

Bioink, GelMA, Gelatin methacrylamide, Gelatin methacrylate, Gelatin methacryloyl

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10 ML
R$ 3.745,00

R$ 3.745,00


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10 ML
R$ 3.745,00

About This Item

Código UNSPSC:
12352201
NACRES:
NA.23

R$ 3.745,00


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Nível de qualidade

descrição

suitable for 3D bioprinting applications
with LAP photoinitiator

esterilidade

sterile-filtered

Formulário

viscous liquid

Impurezas

≤5 CFU/g Bioburden (Fungal)
≤5 CFU/g Bioburden (Total Aerobic)
<50 EU/mL Endotoxin

cor

colorless to pale yellow

tamanho de partícula

0.2 μm

pH

6.5-7.5

aplicação(ões)

3D bioprinting

temperatura de armazenamento

2-8°C

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Categorias relacionadas

Aplicação

TissueFab® GelMA-Vis-LAP bioink is a gelatin methacryloyl (GelMA) based bioink for 3D bioprinting applications. LAP is used as the photoinitiator, which allows blue light photocrosslinking of the printed structure. The formulation is optimized for high printing fidelity and cell viability. The low endotoxin level of this product is lower than 50 EU/mL.

Gelatin methacryloyl (GelMA) is a polymerizable hydrogel material derived from natural extracellular matrix (ECM) components. Due to its low cost, abundance, and retention of natural cell binding motifs, gelatin has become a highly sought material for tissue engineering applications. The addition of photocrosslinkable methacrylamide functional groups in GelMA allows the synthesis of biocompatible, biodegradable, and non-immunogenic hydrogels that are stable in biologically relevant conditions and promote cell adhesion, spreading, and proliferation.

Informações legais

TISSUEFAB is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 3


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Y Shi et al.
Biomedical materials (Bristol, England), 13(3), 035008-035008 (2018-01-09)
Three-dimensional bioprinting is an emerging technology for fabricating living 3D constructs, and it has shown great promise in tissue engineering. Bioinks are scaffold materials mixed with cells used by 3D bioprinting to form a required cell-laden structure. In this paper
B Duan et al.
Acta biomaterialia, 10(5), 1836-1846 (2013-12-18)
Tissue engineering has great potential to provide a functional de novo living valve replacement, capable of integration with host tissue and growth. Among various valve conduit fabrication techniques, three-dimensional (3-D) bioprinting enables deposition of cells and hydrogels into 3-D constructs
Wanjun Liu et al.
Biofabrication, 10(2), 024102-024102 (2017-11-28)
Bioinks with shear-thinning/rapid solidification properties and strong mechanics are usually needed for the bioprinting of three-dimensional (3D) cell-laden constructs. As such, it remains challenging to generate soft constructs from bioinks at low concentrations that are favorable for cellular activities. Herein
P Selcan Gungor-Ozkerim et al.
Biomaterials science, 6(5), 915-946 (2018-03-02)
Bioprinting is an emerging technology with various applications in making functional tissue constructs to replace injured or diseased tissues. It is a relatively new approach that provides high reproducibility and precise control over the fabricated constructs in an automated manner
Janet R Xavier et al.
ACS nano, 9(3), 3109-3118 (2015-02-13)
Despite bone's impressive ability to heal after traumatic injuries and fractures, a significant need still exists for developing strategies to promote healing of nonunion defects. To address this issue, we developed collagen-based hydrogels containing two-dimensional nanosilicates. Nanosilicates are ultrathin nanomaterials

Artigos

Bioinks enable 3D bioprinting of tissue constructs for drug screening and transplantation; select suitable bioinks for specific tissue engineering.

Learn how 3D bioprinting is revolutionizing drug discovery with highly-controllable cell co-culture, printable biomaterials, and its potential to simulate tissues and organs. This review paper also compares 3D bioprinting to other advanced biomimetic techniques such as organoids and organ chips.

Questions

  1. Are there any GelMA products suitable for DLP 3D printing, particularly those that are part of the TissueFab line?

    1 answer
    1. Yes, any of GelMA based bioinks, such as 918741, can be used for DLP 3D printing, but some adjustments are needed. The DLP printer should have a heating function, or the bioink needs to be heated before printing to make the GelMA a low viscosity liquid. Additionally, a photo-absorber needs to be added to the bioink to scavenge scattered light.

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