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911879

Sigma-Aldrich

NanoFabTx™ microfluidic - micro

device kit for synthesis of 10-30 μm particles

Sinônimo(s):

Microfluidic kit, Microparticle, NanoFabTx™ device kit, Nanoformulation

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About This Item

Código UNSPSC:
12162002
Código UNSPSC:
41121811
NACRES:
NA.23

descrição

Microfludic device kit for synthesizing 10-30 μm microparticles

Kit components :

  • Microfluidic chip x 1
  • Tubings and accessories

Nível de qualidade

100

aplicação(ões)

advanced drug delivery

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Descrição geral

NanoFabTx™ Microfluidic - micro device kit is designed to work with the NanoFabTx™ - micro reagent kits like (Cat. No. 912212) for the synthesis of 10-30 μm particles. The device kit includes a comprehensive protocol, pre-assembled microfluidic chip manifold, tubing, and required accessories and is compatible with either the Dolomite microfluidics system or a standard syringe pump (compatible microfluidics system or syringe pump required separately).

Aplicação

NanoFabTx™ Microfluidic - micro device kit in combination with the NanoFabTx™ - micro reagent kits (Cat. No. 912212) can be used to create drug-encapsulating polymeric microparticles 10-30 μm in size. Because of the adjustable flow rate, small reaction window, and adjustable concentrations, microfluidic-based synthesis is a powerful tool for fabricating size-controlled particles to encapsulate drugs, small molecules, mRNA, DNA, and proteins. The chip geometries and flow parameters enable facile, scalable synthesis of monodispersed particles with consistent size and drug loading to facilitate rapid formulation screening.

Características e benefícios

  • Simplifies polymer chemistry of microfluidic formulation development for enhancing drug bioavailability
  • Accelerates optimization of drug encapsulation and loading efficiency in microparticles
  • Provides step-by-step microfluidic-based protocols developed and tested by our formulation scientists
  • Minimizes waste of expensive reagents

Informações legais

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

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Andrew Gdowski et al.
Journal of nanobiotechnology, 16(1), 12-12 (2018-02-13)
The process of optimization and fabrication of nanoparticle synthesis for preclinical studies can be challenging and time consuming. Traditional small scale laboratory synthesis techniques suffer from batch to batch variability. Additionally, the parameters used in the original formulation must be
Samar Damiati et al.
Genes, 9(2) (2018-02-22)
Microfluidic devices present unique advantages for the development of efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Compared to bulk methods, by efficiently controlling the geometries of the fabricated chip and the flow
Xuanyu Li et al.
Advanced drug delivery reviews, 128, 101-114 (2017-12-27)
Microfluidic chips allow the rapid production of a library of nanoparticles (NPs) with distinct properties by changing the precursors and the flow rates, significantly decreasing the time for screening optimal formulation as carriers for drug delivery compared to conventional methods.

Artigos

NanoFabTx™ Drug Delivery Formulations

NanoFabTx™ platform accelerates drug development with ready-to-use formulations and microfluidic devices for particle synthesis.

NanoFabTx™ Nanoparticle Formulation

NanoFabTX kits enable precise drug delivery with lipid nanoparticles and liposomes for mRNA and nucleic acids.

Flash NanoPrecipitation (FNP) – Principles and Applications in Medical Imaging and Drug Delivery

Professor Robert K. Prud’homme introduces flash nanoprecipitation (FNP) for nanoparticle fabrication, which is a scalable, rapid mixing process for nanoparticle formulations.

Microfluidics for Nanoencapsulation of Nucleic Acids

Microfluidic assembly improves polyamine nanoencapsulation of nucleic acids, overcoming challenges like polydispersity and poor reproducibility.

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