855022

Friedelin

technical grade

• Sinônimo(s): (4β,5β,8α,9β,10α,13α,14β)-5,9,13-Trimethyl-24,25,26-trinoroleanan-3-one, DA-friedooleanan-3-one, Friedelan-3-one
• Fórmula empírica (Notação de Hill): C₃₀H₅₀O
• Número CAS: 559-74-0
• Peso molecular: 426.72
• Beilstein: 1916451
• Número CE: 209-205-1
• Número MDL: MFCD00017296
• Código UNSPSC: 12352115
• ID de substância PubChem: 24888367
• NACRES: NA.22

Propriedades

• grau: technical grade
• Formulário: solid
• pf: 262-265 °C (lit.)
• grupo funcional: ketone
• cadeia de caracteres SMILES: C[C@H]1C(=O)CC[C@@H]2[C@]1(C)CC[C@H]3[C@@]2(C)CC[C@@]4(C)[C@@H]5CC(C)(C)CC[C@]5(C)CC[C@]34C
• InChI: 1S/C30H50O/c1-20-21(31)9-10-22-27(20,5)12-11-23-28(22,6)16-18-30(8)24-19-25(2,3)13-14-26(24,4)15-17-29(23,30)7/h20,22-24H,9-19H2,1-8H3/t20-,22+,23-,24+,26+,27+,28-,29+,30-/m0/s1
• chave InChI: OFMXGFHWLZPCFL-SVRPQWSVSA-N

Descrição

Descrição geral

Friedelin, a pentacyclic triterpene, is found in several plants like Cissus quadrangularis, Celastrus vulcanicola, Terminalia avicennioides, and Alangium salvifolium. It is known to act as a histamine H1 receptor (H1R) antagonist, anti-microbial, anti-HIV, and anti-cancer agent.[1][2][3]

Aplicação

Friedelin can be used as a starting material in the synthesis of:

• Friedel-3-enol acetate, friedel-2-oxo-3-enol acetate, friedel-2-ene derivatives[3] and friedelin ketoxime.[4]
• Oxygenated friedelin derivatives as potent DNA topoisomerase IIα inhibitors.[5]
• Its 1,4-pyrazine derivatives as potent antimicrobial agents.[6]

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)