532703

1-Bromo-4-chloro-2-fluorobenzene

98%

• Fórmula linear: BrC₆H₃(Cl)F
• Número CAS: 1996-29-8
• Peso molecular: 209.44
• Número MDL: MFCD00079708
• Código UNSPSC: 12352100
• ID de substância PubChem: 24877906
• NACRES: NA.22

Propriedades

• Ensaio: 98%
• índice de refração: n20/D 1.556 (lit.)
• p.e.: 91-92 °C/20 mmHg (lit.)
• densidade: 1.678 g/mL at 25 °C (lit.)
• cadeia de caracteres SMILES: Fc1cc(Cl)ccc1Br
• InChI: 1S/C6H3BrClF/c7-5-2-1-4(8)3-6(5)9/h1-3H
• chave InChI: FPNVMCMDWZNTEU-UHFFFAOYSA-N

Descrição

Descrição geral

1-Bromo-4-chloro-2-fluorobenzene is a polyhalo substituted benzene. It undergoes Suzuki coupling with 2-cyanoarylboronic esters to form the corresponding biphenyls. These biphenyls are the precursors for synthesizing 6-substituted phenanthridines.† The enthalpy of vaporization at boiling point (467.15K) of 1-bromo-4-chloro-2-fluorobenzene is 40.737kjoule/mol.{4}

Aplicação

1-Bromo-4-chloro-2-fluorobenzene may be used in the preparation of benzonorbornadiene derivative. It may also be used as a starting material in the multi-step synthesis of AZD3264, an IKK2 (inhibitor of nuclear factor κ-B kinase-2) inhibitor.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): 198.0 °F - closed cup
• Ponto de fulgor (°C): 92.2 °C - closed cup
• Equipamento de proteção individual: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)