426016

4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione

99%

• Fórmula empírica (Notação de Hill): C₈H₅F₃O₃
• Número CAS: 326-90-9
• Peso molecular: 206.12
• Número CE: 206-315-1
• Número MDL: MFCD00020935
• Código UNSPSC: 12352100
• ID de substância PubChem: 24866679
• NACRES: NA.22

Propriedades

• Ensaio: 99%
• forma: liquid
• índice de refração: n20/D 1.528 (lit.)
• pb: 203 °C (lit.)
• pf: 19-21 °C (lit.)
• densidade: 1.391 g/mL at 25 °C (lit.)
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: FC(F)(F)C(=O)CC(=O)c1ccco1
• InChI: 1S/C8H5F3O3/c9-8(10,11)7(13)4-5(12)6-2-1-3-14-6/h1-3H,4H2
• chave InChI: OWLPCALGCHDBCN-UHFFFAOYSA-N

Descrição

Descrição geral

4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione (furoyltrifluoroacetone, FTFA) is a β-diketone. Its cytotoxic activity against human cultured tumor and normal cells has been evaluated. Reports suggest that 4,4,4-trifluoro-1-(2-furyl)-1,3-butanedione partially inhibits the oxidation of ferrocyanide in ETP (electron transport particles) isolated from beef heart mitochondria. Its reaction with N,N,N′,N′-tetramethylalkyl diamines to form ionic adducts has been investigated. The conformational analysis of the enol and keto form of FTFA has been reported.

Aplicação

4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione (tfa) may be used in the following studies:

• As capping ligand in the synthesis of [Eu(tfa)₃]₂bpm complexes (bpm=2,2′-bipyrimidine).
• As reagent in the multistep synthesis of [¹³CD₂]benzylamine.
• As reagent in the synthesis of 3-trifluoromethyl-2-arylcarbonylquinoxaline 1,4-di-N-oxide derivatives by reacting with corresponding benzofurazan oxides.
• In the efficient syntheses of perfluoroalkyl substituted azoles.
• Synthesis of 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): 188.6 °F - closed cup
• Ponto de fulgor (°C): 87 °C - closed cup
• Equipamento de proteção individual: Eyeshields, Gloves, type ABEK (EN14387) respirator filter