390690

(2-Hydroxypropyl)-α-cyclodextrin

average M_w ~1,180

• Sinônimo(s): α‐HPCD, 2OHpαCD, 2‐hydroxypropyl‐α‐CD, HPαCD, HP-α-CD
• Número CAS: 128446-33-3
• Número MDL: MFCD00197866
• Código UNSPSC: 12352201
• NACRES: NA.22

Propriedades

• Formulário: powder
• atividade óptica: [α]20/D +125°, c = 1 in H₂O
• peso molecular: average M_w ~1,180
• Extensão da rotulagem: 0.6 molar substitution
• pf: 245 °C (dec.) (lit.)
• cadeia de caracteres SMILES: O1[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@@H]([C@@H](O[C@H]4O[C@@H]([C@@H](O[C@H]5O[C@@H]([C@@H](O[C@H]6O[C@@H]([C@@H](O[C@H]7O[C@@H]([C@@H]1[C@H]([C@@H]7O)O)COCC(O)C)[C@H]([C@@H]6O)O)COCC(O)C)[C@H]([C@@H]5O)O)COCC(O)C)[C@H]([C@@H]4O)O)COCC(O)C)[C@H]([C@@H]3O)O)C
• InChI: 1S/C54H96O36/c1-19(55)7-73-13-25-43-31(61)37(67)49(79-25)86-44-26(14-74-8-20(2)56)81-51(39(69)33(44)63)88-46-28(16-76-10-22(4)58)83-53(41(71)35(46)65)90-48-30(18-78-12-24(6)60)84-54(42(72)36(48)66)89-47-29(17-77-11-23(5)59)82-52(40(70)34(47)64)87-45-27(15
• chave InChI: PMPYGZCSMCXHTA-WABPNHHRSA-N

Descrição

Descrição geral

(2-Hydroxypropyl)-α-cyclodextrin is a hydroxyalkyl derivative of cyclodextrin, which is generally used as a substitute of α-cyclodextrin for potential application in food, cosmetics and pharmaceutical industries. It may be used as a parenteral drug carrier on account of its attractive characteristics such as: a greater extent of solubility in water, high dissolution capacity for weakly soluble analytes, and low toxicity.[1][2]

Aplicação

• (2-Hydroxypropyl)-α-cyclodextrin can be used as a chiral selector to resolve tryptophan racemate by capillary electrophoresis.[3]
• It can be used to synthesize biodegradable polyrotaxanes for fabricating blood-contacting devices.[4]
• Co-polymer based on (2-hydroxypropyl)-α-cyclodextrin cross-linked with polyethylenimine can be used as a gene delivery vector.[5]
• It can also be used as stabilizer for antibacterial iodine formulations, as it forms a stable inclusion complex with iodine and improves aqueous solubility.[6]

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)