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371858

Sigma-Aldrich

6-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole hydrochloride

97%

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About This Item

Fórmula empírica (Notação de Hill):
C12H14N2O · HCl
Número CAS:
35764-54-6
Peso molecular:
238.71
Número MDL:
MFCD00075570
Código UNSPSC:
12171500
ID de substância PubChem:
24863132

Ensaio

97%

pf

288-290 °C (lit.)

cadeia de caracteres SMILES

Cl[H].COc1ccc2[nH]c3CNCCc3c2c1

InChI

1S/C12H14N2O.ClH/c1-15-8-2-3-11-10(6-8)9-4-5-13-7-12(9)14-11;/h2-3,6,13-14H,4-5,7H2,1H3;1H

chave InChI

KRMJEIDSHZEQHJ-UHFFFAOYSA-N

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Classificações de perigo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
03704LX

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J O Marcusson et al.
Molecular pharmacology, 30(2), 121-128 (1986-08-01)
Recently, a high affinity [3H]imipramine-binding site of protein nature that appeared to be related to the 5-hydroxytryptamine (5-HT, serotonin) uptake mechanism was demonstrated. This binding site was only part of desipramine-displaceable [3H]imipramine binding, which contained a significant amount of additional
R Pähkla et al.
Pharmacological research, 34(1-2), 73-78 (1996-07-01)
Pinoline (6-methoxy-1,2,3,4-tetrahydro-beta-carboline) is a naturally occurring compound in the mammalian body which inhibits serotonin (5-hydroxytryptamine) uptake and monoamine oxidase-A activity. The present study was designed to assess potential antidepressant- or anxiolytic-like behavioural effects of pinoline in rat forced swimming, open
M Aranda et al.
Journal of pineal research, 49(1), 78-85 (2010-06-08)
The protective in vivo effects of melatonin or pinoline on carbon tetrachloride (CCl(4))-induced oxidative damage were investigated in liver of rats and compared to rats injected only with CCl(4) (5 mL/kg body weight). Hepatic cell membrane fluidity, monitored using fluorescence
Sergio Millán-Plano et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 17(1), 39-44 (2003-05-21)
The serum concentrations of aluminum, a metal potentially involved in the pathogenesis of Alzheimer's disease, increase with age. Also, intense and prolonged exposure to aluminum may result in dementia. Melatonin and pinoline are two well known antioxidants that efficiently reduce
D L Taylor et al.
Research communications in chemical pathology and pharmacology, 47(1), 133-136 (1985-01-01)
6-MeOTHBC binds to both high and low affinity receptors in human platelets. The beta-carboline is less active than chlorimipramine at the low affinity site, and it is weaker than methysergide, a known 5-HT antagonist, at the high affinity site. The
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