196967
2-Amino-5-trifluoromethyl-1,3,4-thiadiazole
97%
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About This Item
Fórmula empírica (Notação de Hill):
C3H2F3N3S
Número CAS:
Peso molecular:
169.13
Número CE:
Número MDL:
Código UNSPSC:
12352100
ID de substância PubChem:
NACRES:
NA.22
Produtos recomendados
Ensaio
97%
forma
solid
pf
225-227 °C (lit.)
solubilidade
methanol: soluble 0.25 g/10 mL, clear, colorless
grupo funcional
fluoro
cadeia de caracteres SMILES
Nc1nnc(s1)C(F)(F)F
InChI
1S/C3H2F3N3S/c4-3(5,6)1-8-9-2(7)10-1/h(H2,7,9)
chave InChI
LTEUXHSAYOSFGQ-UHFFFAOYSA-N
Aplicação
2-Amino-5-trifluoromethyl-1,3,4-thiadiazole was used in the synthesis of:
- series of 2-sulfonamido/trifluoromethyl-6-(4′-substituted aryl/heteroaryl)imidazo[2,1-b]-1,3,4-thiadiazole derivatives
- 2-trifluoromethyl/sulfonamido-5,6-diarylsubstituted imidazo[2,1-b]-1,3,4-thiadiazole derivatives
- bicyclic bridgehead itrogen heterocycles
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Órgãos-alvo
Respiratory system
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
dust mask type N95 (US), Eyeshields, Gloves
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Bridgehead nitrogen heterocycles. II. Formation by reaction of. alpha.-amino nitrogen heterocyclic compounds with chlorothioformyl chloride.
Pilgram K and Skiles RD.
The Journal of Organic Chemistry, 38(8), 1575-1578 (1973)
Andanappa K Gadad et al.
Bioorganic & medicinal chemistry, 12(21), 5651-5659 (2004-10-07)
A series of 2-sulfonamido/trifluoromethyl-6-(4'-substituted aryl/heteroaryl)imidazo[2,1-b]-1,3,4-thiadiazole derivatives (II) have been synthesized by reaction of 2-amino-5-sulfonamido/trifluoromethyl-1,3,4-thiadiazoles and an appropriate alpha-haloaryl/heteroaryl ketones. Further 5-bromo (III), 5-thiocyanato (IV), 5-gaunylhydrazone (V) derivatives were synthesized in order to study the effect of these substituents on biological
Andanappa K Gadad et al.
Bioorganic & medicinal chemistry, 16(1), 276-283 (2007-10-17)
A series of 2-trifluoromethyl/sulfonamido-5,6-diarylsubstituted imidazo[2,1-b]-1,3,4-thiadiazole derivatives 15a-j have been synthesized by the reaction of 2-amino-5-trifluoromethyl/sulfonamido-1,3,4-thiadiazoles 14a-b and appropriately substituted alpha-bromo-1,2-(p-substituted)diaryl-1-ethanones 13a-h. Structures of these compounds were established by IR, (1)H NMR, (13)C NMR, Mass, and HRMS data. The selected compounds
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