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Merck

PIK3CA

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

Sinônimos:
CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha
Espécies:
Human PIK3CA (5290), Mouse Pik3ca (18706), Rat Pik3ca (170911), sheep PIK3CA (101110015), chicken PIK3CA (424971), dog PIK3CA (488084), domestic guinea pig Pik3ca (100735084), naked mole-rat Pik3ca (101711934), domestic cat PIK3CA (101097413), cow PIK3CA (282306)
ID UniProtKB:
P42336, Q14CW1, Q99762
ID do gene:
  • Human(5290) Summary: Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. [provided by RefSeq, Jul 2008]
  • Mouse(18706) phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
  • Rat(170911) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • sheep(101110015) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • chicken(424971) phosphoinositide-3-kinase, catalytic, alpha polypeptide
  • dog(488084) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • domestic guinea pig(100735084) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • naked mole-rat(101711934) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • domestic cat(101097413) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • cow(282306) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

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Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
SAB5300225
Monoclonal Anti-PIK3CA antibody produced in mouse, clone 4F3, purified immunoglobulin, buffered aqueous solution,
Reatividade de espécies
human
Aplicação
ELISA
flow cytometry
immunofluorescence
western blot
SAB2701957
Anti-PIK3CA antibody produced in rabbit, ,
Reatividade de espécies
human, mouse
Aplicação
immunofluorescence
immunohistochemistry
western blot
AMAB91514
Monoclonal Anti-PIK3CA antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL8347, purified immunoglobulin, buffered aqueous glycerol solution,
Reatividade de espécies
human
Aplicação
immunohistochemistry
SAB5700234
Anti-PIK3CA antibody produced in rabbit, ,
Reatividade de espécies
human, mouse, rat
Aplicação
immunohistochemistry
western blot
ZRB1712
Anti-PI-3 kinase p110α Antibody, clone 1J4 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reatividade de espécies
human, monkey
Aplicação
affinity binding assay
flow cytometry
immunohistochemistry
western blot

Cell Lines

Número do produto
Descrição
Espécies
CLLS1003
DLD1 Cells PIK3CA +/-, ,
Espécies
human
CLLS1199
MCF10A CELLS PTEN (-/-) PIK3CA H1047R (+/-), ,
Espécies
human

Small Molecule - Inhibitor

Número do produto
Descrição
Espécies
PZ0235
PF-04691502, ≥98% (HPLC),
Espécies
human

Kits

Número do produto
Descrição
Espécies
33-047
PI 3-Kinase 3-step HTRF® Assay, The PI 3-Kinase 3-Step HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format.,
Espécies
human
33-04A
PI 3-Kinase 3-step HTRF® Assay, Everything you need to perform the PI3 Kinase 3-step HTRF assays (1920 wells).,
Espécies
human
33-017
PI 3-Kinase HTRF® Assay; 1920 wells, The PI 3-Kinase HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format. This pack size has a screening capacity of 5 plates.,
Espécies
human
33-036
PI 3-Kinase HTRF® Assay; 10,000 wells, The PI 3-Kinase HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format. This pack size has a screening capacity of 10,000 wells.,
Espécies
human
33-037
PI 3-Kinase HTRF® Assay; 50,000 wells, The PI 3-Kinase HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format. This pack size has a screening capacity of 50,000 wells.,
Espécies
human

Proteins

Número do produto
Descrição
Espécies
14-602-M
PI3 Kinase (p110α/p85α) Protein, active, 20 µg, Active complex of N-terminal His6-tagged recombinant full-length human p110α & untagged, recombinant, full length, human p85α. For use in Kinase Assays.,
Espécies
human
SRP0233
PI3 kinase (p110a/p85a) Active human, recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE),
Espécies
human
14-790-M
PI3 Kinase (p110α/p65α), 10 µg, Complex of N-terminal 6His-tagged, recombinant, full-length Human p110α & untagged, recombinant, full length Human p65α. For use in Kinase Assays.,
Espécies
human
14-783-M
PI3 Kinase (p110α(E545K)/p85α), 10 µg, Complex of N-terminal 6His-tagged, recombinant, full-length human p110α containing the mutation E545K & untagged, recombinant, full-length human p85α. For use in Kinase Assays.,
Espécies
human
14-787-M
PI3 Kinase (p110α (H1047R)/p85α) Murine, 10 µg, Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α containing the mutation H1047R α & untagged, recombinant, full length mouse p85α. For use in Kinase Assays.,
Espécies
mouse

esiRNA

Número do produto
Descrição
Espécies
EHU231281
MISSION® esiRNA, targeting human PIK3CA (2),
Espécies
human
EHU039391
MISSION® esiRNA, targeting human PIK3CA,
Espécies
human
EMU053821
MISSION® esiRNA, targeting mouse Pik3ca,
Espécies
mouse