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Merck

NCF4

neutrophil cytosolic factor 4, 40kDa

Sinônimos:
NCF, P40PHOX, SH3PXD4
Espécies:
ID UniProtKB:
ID do gene:
  • Human(4689) Summary: The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
  • Mouse(17972) neutrophil cytosolic factor 4
  • Rat(500904) neutrophil cytosolic factor 4
  • chicken(418052) neutrophil cytosolic factor 4, 40kDa
  • Zebrafish(403014) neutrophil cytosolic factor 4
  • domestic cat(101095507) neutrophil cytosolic factor 4, 40kDa
  • dog(481277) neutrophil cytosolic factor 4, 40kDa
  • cow(507859) neutrophil cytosolic factor 4, 40kDa
  • Horse(100069566) neutrophil cytosolic factor 4, 40kDa
  • sheep(101122939) neutrophil cytosolic factor 4, 40kDa
  • Domestic Rabbit(100009359) neutrophil cytosolic factor 4, 40kDa
  • domestic guinea pig(100729267) neutrophil cytosolic factor 4, 40kDa
  • naked mole-rat(101699188) neutrophil cytosolic factor 4, 40kDa

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Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
Anti-NCF4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reatividade de espécies
human
Aplicação
immunohistochemistry
Anti-NCF4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reatividade de espécies
human
Aplicação
immunofluorescence
Anti-NCF4 antibody produced in rabbit, affinity isolated antibody,
Reatividade de espécies
guinea pig, horse, human, rat
Aplicação
western blot
Anti-NCF4 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Reatividade de espécies
human
Aplicação
western blot
Anti-NCF4/p40-phox Antibody, clone 4L9Z4, Rabbit Monoclonal, ,
Reatividade de espécies
mouse
Aplicação
immunohistochemistry
immunoprecipitation (IP)

western blot

Proteins

Número do produto
Descrição
Espécies
Cytosol from Liver, Pooled, from human,
Espécies
human

esiRNA

Número do produto
Descrição
Espécies
MISSION® esiRNA, targeting human NCF4,
Espécies
human
MISSION® esiRNA, targeting mouse Ncf4,
Espécies
mouse