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Merck

HTR2C

5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled

Sinônimos:
5-HT2C, 5-HTR2C, HTR1C
Espécies:
Human HTR2C (3358), Mouse Htr2c (15560), Rat Htr2c (25187), domestic cat HTR2C (101099620), naked mole-rat Htr2c (101726296), Horse HTR2C (100057852), cow HTR2C (538909), dog HTR2C (450240), chicken HTR2C (428707)
ID UniProtKB:
P28335, B1AMW4, Q5VUF8, Q9NP28
ID do gene:
  • Human(3358) Summary: Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
  • Mouse(15560) 5-hydroxytryptamine (serotonin) receptor 2C
  • Rat(25187) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • domestic cat(101099620) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • naked mole-rat(101726296) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • Horse(100057852) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • cow(538909) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • dog(450240) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • chicken(428707) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled

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Small Molecule - Agonist

Número do produto
Descrição
Espécies
M110
α-Methylserotonin maleate salt, ≥98% (HPLC),
Espécies
human
C117
5-Carboxamidotryptamine maleate salt, powder, ≥98% (HPLC),
Espécies
human, rat
Q1004
Quipazine maleate salt, ,
Espécies
human

Small Molecule - Allosteric Modulator

Número do produto
Descrição
Espécies
D9190
DCEBIO, ≥98% (HPLC), solid,
Espécies
human

Small Molecule - Antagonist

Número do produto
Descrição
Espécies
142360
4-Benzylpiperidine, 99%,
Espécies
rat
C-060
Cyclobenzaprine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Espécies
human
300764
1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole, 98%,
Espécies
rat
BP886
Cyclobenzaprine hydrochloride, British Pharmacopoeia (BP) Reference Standard,
Espécies
human
C3200000
Cyclobenzaprine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Espécies
human

Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
SAB4501477
Anti-5-HT-2C antibody produced in rabbit, affinity isolated antibody,
Reatividade de espécies
human, mouse, rat
Aplicação
ELISA
immunofluorescence
immunohistochemistry
SAB4501478
Anti-HTR2C antibody produced in rabbit, affinity isolated antibody,
Reatividade de espécies
human, mouse, rat
Aplicação
ELISA
western blot
SAB2500925
Anti-Serotonin Receptor 2C/HTR2C antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reatividade de espécies
canine, human, mouse, rat
Aplicação
ELISA
western blot

Small Molecule - Blocker

Número do produto
Descrição
Espécies
Z101
Zimelidine dihydrochloride, solid,
Espécies
human

Small Molecule - Inhibitor

Número do produto
Descrição
Espécies
T-030
Trazodone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Espécies
human
R0875
Reserpine, ,
Espécies
human
I119
Indatraline hydrochloride, solid,
Espécies
human
M8046
Mifepristone, ≥98%,
Espécies
human, mouse, rat
51330
Harmaline, ≥95%,
Espécies
human, rat

Small Molecule - Ligand

Número do produto
Descrição
Espécies
M1514
Nω-Methyl-5-hydroxy­trypt­amine oxalate salt, ≥90% (HPLC),
Espécies
human

Small Molecule - Metabolite

Número do produto
Descrição
Espécies
H8876
5-Hydroxyindole-3-acetic acid, ≥98% (HPLC), crystalline,
Espécies
human

Small Molecule - Mixed Agonist/Antagonist

Número do produto
Descrição
Espécies
M8046
Mifepristone, ≥98%,
Espécies
human, mouse, rat

Small Molecule - Precursor

Número do produto
Descrição
Espécies
H9772
5-Hydroxy-L-tryptophan, powder,
Espécies
human

Proteins

Número do produto
Descrição
Espécies
HTS132M
ChemiSCREEN Human 5-HT2C Receptor Membrane Preparation, Human 5-HT2C GPCR membrane preparation for Radioligand binding Assays & GTPγS binding.,
Espécies
human

esiRNA

Número do produto
Descrição
Espécies
EHU120291
MISSION® esiRNA, targeting human HTR2C,
Espécies
human