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Merck

COMT

catechol-O-methyltransferase

Sinônimos:
Espécies:
ID UniProtKB:
ID do gene:
  • Human(1312) Summary: Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
  • Mouse(12846) catechol-O-methyltransferase
  • Rat(24267) catechol-O-methyltransferase
  • cow(618278) catechol-O-methyltransferase
  • domestic guinea pig(100730509) catechol-O-methyltransferase
  • domestic cat(101097022) catechol-O-methyltransferase
  • naked mole-rat(101717730) catechol-O-methyltransferase
  • chicken(416783) catechol-O-methyltransferase
  • Horse(100146509) catechol-O-methyltransferase
  • fruit fly(47091) comatose
  • dog(445450) catechol-O-methyltransferase

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Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
Anti-Catechol O-methyltransferase/COMT Antibody, from rabbit, purified by affinity chromatography,
Reatividade de espécies
bovine, horse, human, porcine, rhesus macaque
Aplicação
immunohistochemistry
western blot
Anti-COMT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reatividade de espécies
human, rat
Aplicação
western blot
Anti-COMT antibody produced in rabbit, affinity isolated antibody,
Reatividade de espécies
human
Aplicação
ELISA
western blot
Monoclonal Anti-COMT antibody produced in mouse, clone 1G4-1A1, purified immunoglobulin, buffered aqueous solution,
Reatividade de espécies
human
Aplicação
ELISA
western blot
Anti-COMT antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Reatividade de espécies
human
Aplicação
western blot

Small Molecule - Inhibitor

Número do produto
Descrição
Espécies
Ro 41-0960, solid,
Espécies
human
3,5-Dinitrocatechol, solid,
Espécies
human

esiRNA

Número do produto
Descrição
Espécies
MISSION® esiRNA, targeting human COMT,
Espécies
human