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B2635

Supelco

Busulfan

analytical standard, for drug analysis

Synonym(s):

1,4-Butanediol dimethanesulfonate

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About This Item

Linear Formula:
CH3SO2O(CH2)4OSO2CH3
CAS Number:
55-98-1
Molecular Weight:
246.30
Beilstein:
1791786
EC Number:
200-250-2
MDL number:
MFCD00007562
UNSPSC Code:
41116107
PubChem Substance ID:
329773205
NACRES:
NA.24

grade

analytical standard, for drug analysis

Quality Level

100

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

114-117 °C (lit.)

application(s)

forensics and toxicology
veterinary

format

neat

SMILES string

CS(=O)(=O)OCCCCOS(C)(=O)=O

InChI

1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3

InChI key

COVZYZSDYWQREU-UHFFFAOYSA-N

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General description

Busulfan is a bifunctional alkylating agent, which may find application in the treatment of chronic granulocytic leukemia.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H301,H340,H350,H360FD

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1A - Muta. 1B - Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF3873V
BCCK8828
BCCG5556
BCCF4469
BCCC6140

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Edward A Copelan et al.
Blood, 122(24), 3863-3870 (2013-09-26)
Cyclophosphamide combined with total body irradiation (Cy/TBI) or busulfan (BuCy) are the most widely used myeloablative conditioning regimens for allotransplants. Recent data regarding their comparative effectiveness are lacking. We analyzed data from the Center for International Blood and Marrow Transplant
Christopher Bredeson et al.
Blood, 122(24), 3871-3878 (2013-10-02)
We conducted a prospective cohort study testing the noninferiority of survival of ablative intravenous busulfan (IV-BU) vs ablative total body irradiation (TBI)-based regimens in myeloid malignancies. A total of 1483 patients undergoing transplantation for myeloid malignancies (IV-BU, N = 1025;
Blood and Marrow Stem Cell Transplantation: Principles, Practice, and Nursing Insights (1997)
Joel A Spencer et al.
Nature, 508(7495), 269-273 (2014-03-05)
Characterization of how the microenvironment, or niche, regulates stem cell activity is central to understanding stem cell biology and to developing strategies for the therapeutic manipulation of stem cells. Low oxygen tension (hypoxia) is commonly thought to be a shared
Dharma Choudhary et al.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 19(3), 492-495 (2012-11-20)
Hematopoietic stem cell transplantation (HSCT) is the definite treatment for patients with thalassemia major. A busulfan (Bu) and cyclophosphamide (Cy)-based regimen has been the standard myeloablative chemotherapy, but it is associated with higher treatment-related toxicity, particularly in patients classified as
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