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Key Documents

B1170000

Busulfan

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Busulfan, 1,4-Butanediol dimethanesulfonate

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About This Item

Linear Formula:
CH3SO2O(CH2)4OSO2CH3
CAS Number:
Molecular Weight:
246.30
Beilstein:
1791786
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

busulfan

manufacturer/tradename

EDQM

mp

114-117 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CS(=O)(=O)OCCCCOS(C)(=O)=O

InChI

1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3

InChI key

COVZYZSDYWQREU-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Busulfan EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1A - Muta. 1B - Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Ibrahim El-Serafi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 913-914, 98-105 (2013-01-05)
Busulphan is an alkylating agent used as conditioning regimen prior to stem cell transplantation. Busulphan is metabolized in the liver and four major metabolites have been identified. The first metabolite is tetrahydrothiophene which is oxidized to tetrahydrothiophene 1-oxide, then sulfolane
Je-Hwan Lee et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(6), 701-709 (2012-11-07)
We conducted a phase III randomized clinical trial to compare two myeloablative conditioning regimens for allogeneic hematopoietic cell transplantation (HCT) in patients with leukemia and myelodysplastic syndrome. After randomization, 64 patients received busulfan (3.2 mg/kg per day × 4 days)
Dharma Choudhary et al.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 19(3), 492-495 (2012-11-20)
Hematopoietic stem cell transplantation (HSCT) is the definite treatment for patients with thalassemia major. A busulfan (Bu) and cyclophosphamide (Cy)-based regimen has been the standard myeloablative chemotherapy, but it is associated with higher treatment-related toxicity, particularly in patients classified as
R T Silver et al.
Blood, 94(5), 1517-1536 (1999-09-09)
Because there are differing opinions regarding treatment of patients in the chronic phase of chronic myeloid leukemia (CML), the American Society of Hematology convened an expert panel to review and document evidence-based benefits and harms of treatment of CML with
Moustapha Hassan et al.
Pharmacogenomics, 14(1), 75-87 (2012-12-21)
Hematopoietic stem cell transplantation (HSCT) is a curative treatment for several malignant and nonmalignant disorders. Busulfan (Bu) and cyclophosphamide (Cy) are the most commonly used alkylators in high-dose pretransplant conditioning for HSCT; a treatment that is correlated with drug-related toxicity

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