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T0576

Sigma-Aldrich

Tau-441 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder

Synonym(s):

Human Tau Protein, Tau Protein

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About This Item

MDL number:
UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

Quality Level

recombinant

expressed in E. coli

Assay

≥90% (SDS-PAGE)

form

lyophilized powder

mol wt

45.9 kDa

UniProt accession no.

application(s)

cell analysis

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... MAPT(4137)

General description

Tau-441 human, recombinant, is an isoform of Tau, variant 2N4R, having 4 microtubule binding repeats (R) and 2 amino terminal inserts (N). Tau is a family of neuronal microtubule-associated proteins. Tau, a phosphoprotein is considered as an important microtubule associated protein (MAP) of a mature neuron. The 2N4R tau consists of 441 amino acids (tau441) and is considered as the largest size human brain tau. In human brain, tau is present in six molecular isoforms.
The gene microtubule associated protein tau (MAPT) is localized on human chromosome 17q21.3. It is expressed in neurons, more specifically in axons.

Application

Human Tau-441 has been used to study the effects of tau on neuropathological changes in Alzheimer′s disease.
Tau-441 human has been used to study its effects on mitochondrial transport velocities found in glial cells.

Biochem/physiol Actions

Microtubule associated protein tau (MAPT) plays an important role in the assembly and maintenance of the microtubule structure. Loss of expression of MAPT results in developmental delay and learning disability. The protein has been associated with pathology of Alzheimer′s disease (AD).
Tau promotes assembly and stabilizes neuronal microtubules under normal physiological conditions.
Isoform of Tau, variant 2N4R, having 4 microtubule binding repeats (R) and 2 amino terminal inserts (N)

Reconstitution

Lyophilized from MES, pH 6.8, containing NaCl and EGTA. When reconstituted in water to a protein concentration of 1 mg/mL, the resulting buffer will have ~50 mM MES, pH 6.8, 100 mM NaCl, and 0.5 mM EGTA.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Preliminary study of effect of exogenous tau-441 on mitochondrial transport in glia.
Morgan MX
wheaton journal of neurobiology research (2017)
Seed-competent HMW tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients
Shuko Takeda
Annals of Neurology (2016)
Tau in Alzheimer Disease and Related Tauopathies
Iqbal K, et al.
Current Alzheimer Research, 7(8), 656-656 (2010)
Microdeletion encompassing MAPT at chromosome 17q21. 3 is associated with developmental delay and learning disability
Shaw-Smith, Charles, et al
Nature Genetics, 38 (2006)
The H1c haplotype at the MAPT locus is associated with Alzheimer's disease
A. J. Myers
Human Molecular Genetics, 14 (2005)

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