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HybridSPE®-PLus 96-Well solid phase extraction (SPE) Plate

Volume 2 mL, bed wt., 50 mg, pk of 1 ea

Synonyme(s) :

HybridSPE®-PLus

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About This Item

Code UNSPSC :
41104018
Nomenclature NACRES :
NB.21

product name

HybridSPE®-PLus 96-Well Plate, volume 2 mL, pk of 1 ea

Description

96-well Plate

Niveau de qualité

100

Gamme de produits

HybridSPE®

Composition

bed wt., 50 mg

Conditionnement

pk of 1 ea

Technique(s)

solid phase extraction (SPE): suitable

Volume

2 mL

Groupe de la matrice active

zirconia-based phase

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Catégories apparentées

Description générale

HybridSPE-PLus is the next generation of HybridSPE-Phospholipid technology. The first of its kind, HybridSPE-Phospholipid technology was first introduced in 2008. It fuses the simple, standardized methodology of traditional protein precipitation with the specificity of solid phase extraction (SPE) for the simultaneous removal of proteins and phospholipids from biological samples prior to LC-MS analysis. Unlike other phospholipid removal products that use a hydrophobic retention mechanism to remove phsopholipids from biological samples, HybridSPE-Phospholipid technology uses a unique Lewis acid/base retention mechanism that allows it to separate phospholipids from even very hydrophobic analytes, such as vitamins, which are often retained along with phospholipids on competitive products.

Our HybridSPE-PLus products offer the same time-proven chemistry of our traditional HybridSPE-Phospholipid products coupled with manufacturing enhancements that stem from years of production experience. These manufacturing enhancements have allowed us to increase flow consistency and reduce sample hold up volumes, further improving analyte recoveries and assay reproducibility. We invite customers to take advantage of the newest technology; HybridSPE-PLus.

Caractéristiques et avantages

  • Simple 2-3 step standard methodology analogous to traditional protein precipitation provides simultaneous removal of both proteins and phospholipids
  • Unique Lewis acid/base retention mechanism effectively removes phospholipids from both hydrophilic and hydrophobic analytes of interest (unlike competitive chemistries) eliminating phospholipid-induced ion suppression
  • Highly reproducible, consistent product performance
  • Provides cleaner samples for longer column life and less instrument downtime
  • Available in 96-well and 1 mL cartridge dimensions

Informations légales

HybridSPE is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Choose from one of the most recent versions:

Certificats d'analyse (COA)

Lot/Batch Number
18346801
18346804
18346803
18346802
18106101

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Articles

Two Distinct Sample Prep Approaches to Overcome Matrix Effect in LC/MS of Serum or Plasma Samples

This article highlights the impact that sample matrix effects can have on LC/MS response and discusses two novel approaches to reduce it.

Method Optimization for LC-MS Analysis of Vitamin D Metabolite Critical Pairs in Serum

Using HybridSPE-Phospholipid, Ascentis Express, and Other LC-MS Workflow Components

Protocoles

Rapid, Sensitive, and Quantitative LC/MS/MS Determination of Digitoxin and Digoxin in Plasma

Immunoassay-based methods for digitoxin or digoxin exist, but are time consuming, labor intensive, and not selective due to similarities in their chemical structures.

LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18

LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18

Contenu apparenté

HPLC de petites molécules

Les petites molécules sont des ions ou des composés d'une masse moléculaire généralement inférieure à 900 daltons. Ces molécules peuvent être séparées efficacement et analysées par HPLC, UHPLC et LC-MS en utilisant essentiellement des particules de silice ou des phases stationnaires monolithiques présentant un large éventail de chimies de colonnes (modifications) différentes.

Small Molecule HPLC

Small molecules are ions and compounds of molecular weight typically less than 900 daltons. These compounds can be effectively separated and analyzed by HPLC, UHPLC and LC-MS using mainly silica particles or monolithic stationary phases with a broad range of column chemistries (modifications).

Extraction en phase solide (SPE)

L'extraction en phase solide (SPE) est une technique rapide et sélective de préparation et de purification d'échantillons avant une analyse chromatographique (du type HPLC, CPG/GC ou CCM/TLC par exemple). La SPE est utilisée pour échanger les matrices des échantillons, concentrer des analytes et éliminer les interférences et les contaminants, afin d'améliorer la qualité des données et de protéger la colonne analytique.

Solid Phase Extraction (SPE)

Solid phase extraction purifies samples for chromatographic analysis, improving data quality and protecting analytical columns.

Chromatograms

application for HPLC, application for SPE

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