T2265

Tetraethylammonium chloride

≥98% (titration)

• Synonyme(s) : TEA chloride
• Formule linéaire : (C₂H₅)₄N(Cl)
• Numéro CAS: 56-34-8
• Poids moléculaire : 165.70
• Numéro Beilstein : 3563247
• Numéro CE : 200-267-5
• Numéro MDL: MFCD00011828
• Code UNSPSC : 12352107
• ID de substance PubChem : 24277874
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: synthetic (organic)
• Pureté: ≥98% (titration)
• Forme: powder
• Technique(s): blocking: suitable
• Couleur: white to light yellow
• Chaîne SMILES: [Cl-].CC[N+](CC)(CC)CC
• InChI: 1S/C8H20N.ClH/c1-5-9(6-2,7-3)8-4;/h5-8H2,1-4H3;1H/q+1;/p-1
• Clé InChI: YMBCJWGVCUEGHA-UHFFFAOYSA-M
• Informations sur le gène: human ... CHRNA1(1134) , CHRNA10(57053) , CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137) , CHRNA5(1138) , CHRNA6(8973) , CHRNA7(1139) , CHRNA9(55584) , CHRNB1(1140) , CHRNB2(1141) , CHRNB3(1142) , CHRNB4(1143)

Description

Application

Tetraethylammonium chloride (TEAC) has been used:

• used for inhibition of peroxynitrite induced relaxation in rat aorta rings
• as a pharmacological blocker of K⁺ current and Ca²⁺ induced K⁺ current in antennal lobe neurons
• for the induction of TEAC sensitive currents in cochlear inner hair cells digested with proteolytic enzymes and analyze its properties

Actions biochimiques/physiologiques

Blocks K⁺ channels; blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K⁺ currents.

Tetraethylammonium chloride (TEAC) blocks K⁺ channels non-specifically. In rat aorta rings, tetraethylammonium inhibits relaxation induced by peroxynitrite. It blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K⁺ currents. TEAC can increase the contractility and mobility of colon and rectum and is a therapeutic option for Hirschsprung′s disease patients. TEAC reduces the inflammatory responses, improves cardiac, vascular and hemodynamic properties during early sepsis in animals. TEAC has cytotoxic and anti-proliferative potential and induces apoptosis in glioma cells by downregulating B-cell lymphoma-2 (Bcl-2) and upregulating Bcl-2 associated X (Bax).

Attention

moisture sensitive, handle under argon

Autres remarques

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319
• Conseils de prudence: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): 201.2 °F - closed cup
• Point d'éclair (°C): 94 °C - closed cup
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves