SML3989

DRP1 Inhibitor, MIDI

≥98% (HPLC)

• Synonyme(s) : 1,1′-(1,4-Phenylene)bis[3-(3-pyridinyl)-2-propen-1-one], MIDI
• Formule empirique (notation de Hill): C₂₂H₁₆N₂O₂
• Numéro CAS: 348145-43-7
• Poids moléculaire : 340.37
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 0.5 mg/mL, clear (Warmed)
• Température de stockage: room temp
• Chaîne SMILES: O=C(/C=C/C1=CC=CN=C1)C2=CC=C(C(/C=C/C3=CC=CN=C3)=O)C=C2

Description

Actions biochimiques/physiologiques

Mitochondrial fission inhibitor that blocks DRP1 recruitment to mitochondria.



DRP1 Inhibitor MIDI is a cell-permeable, symmetrical pyridinyl-propenone compound that acts as a potent, time-dependent mitochondrial fission inhibitor (0.5 - 2 µM) and functionally mimics DRP1 knockout. MIDI is shown to covalently interact with DRP1-C367 and disrupt DRP1 interaction with its mitochondrial receptors MFF and MiD49/51. Blocks stress-induced mitochondrial fragmentation and promotes mitochondrial hyperfusion. MIDI does neither obstruct DRP1 tetramerization nor its GTPase activity. Poorly affects mitochondrial oxygen consumption rate and glycolysis activity.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable