SML2396

α-DHED

≥98% (HPLC)

• Synonyme(s) : 10ß,17a-Dihydroxyestra-1,4-dien-3-one, alpha-DHED
• Formule empirique (notation de Hill) : C₁₈H₂₄O₃
• Numéro CAS: 2362514-18-7
• Poids moléculaire : 288.38
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 2 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: O[C@@]12C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@H]4O)=CC(C=C1)=O
• Clé InChI: UIKDFTLKOKNUJP-ZCVDQKGDSA-N

Description

Actions biochimiques/physiologiques

α-DHED is a bioprecursor prodrug of 17α-estradiol ((Alfatradiol)) that results in 17α-estradiol being produced selectively in the brain with little production in the periphery. α-DHED has no estrogenic activity itself with little affinity for either ERα and ERβ estrogen receptors. 17α-estradiol (αE2) has been proposed to have potential roles in various neurodegenerative disorders including neuroprotection of the brain and the prevention/treatment of Alzheimer′s disease, but peripheral side-effects on estrogen-sensitive organs have been problematic. α-DHED, a prodrug without estrogenic activity, could help alleviate those concerns.

Bioprecursor prodrug of 17α-estradiol that results in 17α-estradiol being produced selectively in the brain

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable