SML1158

(2S)-Hypusine dihydrochloride

≥95% (HPLC)

• Synonyme(s) : (+)-Hypusine dihydrochloride, N6-[(2RS)-4-Amino-2-hydroxybutyl]-L-lysine dihydrochloride
• Formule empirique (notation de Hill): C₁₀H₂₃N₃O₃ · 2HCl
• Poids moléculaire : 306.23
• Code UNSPSC : 12352209
• ID de substance PubChem : 329825688
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to beige
• Solubilité: H₂O: 15 mg/mL, clear
• Température de stockage: −20°C
• Chaîne SMILES: [H]Cl.[H]Cl.N[C@H](C(O)=O)CCCCNCC(O)CCN
• InChI: 1S/C10H23N3O3.2ClH/c11-5-4-8(14)7-13-6-2-1-3-9(12)10(15)16;;/h8-9,13-14H,1-7,11-12H2,(H,15,16);2*1H/t8?,9-;;/m0../s1
• Clé InChI: UTSZZUVUESAPQD-AHBBCRTASA-N

Description

Actions biochimiques/physiologiques

(2S)-Hypusine is an unusual amino acid found only in eukaryotic translation initiation factor 5A (eIF5A) and a similar protein in archaebacteria. (2S)-Hypusine is formed by posttranslational modification of a lysine with the addition of the 4-aminobutyl moiety from the polyamine spermidine. There is increasing interest in the polyamine-hypusine axis and eIF5A, its a role in cell growth and differentiation, and a recent paper on the polyamine-hypusine axis as a potential new tumour suppressor network.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable