SML0506

LY-411575

≥97% (HPLC)

• Synonyme(s) : LSN-411575, LY 411575, N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide
• Formule empirique (notation de Hill) : C₂₆H₂₃F₂N₃O₄
• Numéro CAS: 209984-57-6
• Poids moléculaire : 479.48
• Numéro MDL: MFCD09832551
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825453
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥97% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 5 mg/mL, clear
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Chaîne SMILES: C[C@H](NC(=O)[C@@H](O)c1cc(F)cc(F)c1)C(=O)N[C@@H]2C(=O)N(C)c3ccccc3-c4ccccc24
• InChI: 1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,29,34)(H,30,33)/t14-,22-,23-/m0/s1
• Clé InChI: ULSSJYNJIZWPSB-CVRXJBIPSA-N

Description

Application

LY-411575 has been used as a potent γ-secretase inhibitor and Notch inhibitor.[1][2][3]

Actions biochimiques/physiologiques

LY-411575 is potent, cell permeable and selective γ-secretase inhibitor that reduces Aβ/42 after acute or chronic treatment, and blocks Notch activation. Studies (Cancer Cell) have shown that treatment with LSN-411575 arrests KrasG12V-driven NSCLCs in association with inhibition of HES1 expression and ERK phosphorylation.

LY-411575 is potent, cell permeable and selective γ-secretase inhibitor that reduces Aβ40/42 after acute or chronic treatment, and blocks Notch activation.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable