SAB5500055

Anti-CD25 antibody, Rabbit monoclonal

recombinant, expressed in proprietary host, clone SP176, affinity isolated antibody

• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Produit recombinant: expressed in proprietary host
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: SP176, monoclonal
• Espèces réactives: human (tested)
• Réactivité de l'espèce (prédite par homologie): rat, mouse
• Technique(s): immunohistochemistry: 1:100; western blot: 1:200
• Isotype: IgG
• Numéro d'accès UniProt: P01589
• Conditions d'expédition: wet ice
• Température de stockage: 2-8°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... IL2RA(3559)

Description

Description générale

IL2RA (interleukin 2 receptor subunit α) gene codes for interleukin-2 receptor α-chain CD25. CD25 is expressed on activated T-cells. The activated T-cells liberate this molecule in the form of a soluble variant (referred to as soluble IL-2 receptor; sIL-2R) from the cell membrane into the circulation. The CD25 gene is located on human chromosome 10p15. The gene spans a length of 48kb with eight exons.

Interleukin-2 receptor subunit alpha, also known as CD25, is a type I transmembrane protein and the alpha chain of the IL-2 receptor. CD25 and CD122 form a heterodimer to act as a high-affinity receptor for IL-2. CD25 is expressed on activated T cells, activated B cells, some thymocytes, myeloid precursors, oligodendrocytes, and most B cell neoplasms, some acute nonlymphocytic leukemias, neuroblastomas, and tumor infiltrating lymphocytes.

Immunogène

Synthetic peptide derived from the C-terminus of human CD25 protein.

Actions biochimiques/physiologiques

Interleukin-2 (IL-2) is a cytokine that is essential in modulating activation, proliferation, and survival of several T-cell subsets. IL2RA gene has been associated with susceptibility to multiple sclerosis (MS).

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable