SAB4501174
Anti-Connexin 43 antibody produced in rabbit
affinity isolated antibody
Synonyme(s) :
CX43, CXA1, CXN-43, Connexin 43, Gap junction 43 kDa heart protein
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Poids mol.
antigen 43 kDa
Espèces réactives
mouse, human, rat
Concentration
~1 mg/mL
Technique(s)
ELISA: 1:20000
western blot: 1:500-1:1000
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... GJA1(2697)
Description générale
Connexin 43 belongs to the connexin protein family that forms gap junction. This protein is highly expressed in neurons and radial glia during development and in astrocytes in adult brains.
Connexin 43 belongs to the connexin protein family that forms gap junction. This protein is highly expressed in neurons and radial glia during development and in astrocytes in adult brains.
Immunogène
The antiserum was produced against synthesized peptide derived from human Connexin 43.
Immunogen Range: 332-381
Immunogen Range: 332-381
Application
Anti-Connexin 43, C-Terminal antibody produced in rabbit has been used in flow cytometry.
Actions biochimiques/physiologiques
In rodents, connexin-43 (Cx-43) shows specific temporal patterns of expression during brain development. Experimental studies reveal that, connexin-43 expression increases in the brain during sheep ontogenesis.This protein might play a crucial role in neuronal migration as it resides in radial glial fibers which are closely associated with migrating neurons. It is also involved in transmembrane NAD+ transport. connexin-43, which is an element of gap junction, helps in cell–cell communication. Cx-43 is known to induce [Ca2+] i burst phenomenon in uterine artery endothelial cells (UAECs).
Caractéristiques et avantages
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Forme physique
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
nwg
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Grazyna B Sadowska et al.
Brain research, 1255, 51-56 (2008-12-23)
Gap junctions are specialized membrane structures that mediate intercellular communication and facilitate passage of ions and small molecules between adjacent cells. Connexins comprise a multigene family of transmembrane proteins that form gap junctions. Connexin-32 and connexin-43 are among the most
B Nadarajah et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 17(9), 3096-3111 (1997-05-01)
Gap junctions are membrane channels that mediate the direct passage of ions and molecules between adjacent cells. Recent tracer coupling and optical recording studies have revealed the presence of gap junction-mediated communication between neurons during neocortical development. We have visualized
S Bruzzone et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 15(1), 10-12 (2000-12-02)
A previously unrecognized passive transport for pyridine dinucleotides has been described recently in the plasmamembrane of several mammalian cells. Despite elucidation of some functional and kinetic properties of this transport system, it is still undefined at the molecular level. Therefore
Rosario Gajardo-Gómez et al.
International journal of molecular sciences, 21(7) (2020-04-09)
At least half of human immunodeficiency virus (HIV)-infected individuals suffer from a wide range of cognitive, behavioral and motor deficits, collectively known as HIV-associated neurocognitive disorders (HAND). The molecular mechanisms that amplify damage within the brain of HIV-infected individuals are
Fu-Xian Yi et al.
Biology of reproduction, 82(1), 66-75 (2009-09-11)
Endothelium-mediated vasodilation is specifically enhanced in uterine circulation during pregnancy, and production of nitric oxide (NO) is increased in response to a wide array of agonists. Uterine artery endothelial cells from nonpregnant (NP-UAECs) or pregnant (P-UAECs) ewes maintained in culture
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