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SAB4200191

Sigma-Aldrich

Anti-Septin 9 antibody, Rat monoclonal

clone Clone 1A6C2, purified from hybridoma cell culture

Synonyme(s) :

Anti-MLL, Anti-MSF, Anti-MSF1, Anti-NAPB, Anti-PEANUT-LIKE 4, Anti-PNUTL4, Anti-SEPT9, Anti-SINT1, Anti-SeptD1, Monoclonal Anti-Septin 9 antibody produced in rat

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rat

Conjugué

unconjugated

Forme d'anticorps

purified from hybridoma cell culture

Type de produit anticorps

primary antibodies

Clone

Clone 1A6C2, monoclonal

Forme

buffered aqueous solution

Poids mol.

~72 kDa

Espèces réactives

human, rat, monkey, mouse

Concentration

~1.0 mg/mL

Technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: 2.5-5.0 μg/mL using L929, HeLa, 3T3 and COS-7 cell extracts

Isotype

IgG2a

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... SEPT9(10801)
mouse ... Sept9(53860)
rat ... Sept9(83788)

Description générale

Monoclonal Anti-Septin 9 (rat IgG2a isotype) is derived from the hybridoma 1A6C2 produced by the fusion of mouse myeloma cells and splenocytes from rat immunized with a synthetic peptide of corresponding to the N-terminus of rat Septin 9, conjugated to KLH. Septin 9 (SEPT9) is a member of the septin family (also designated MSF/eseptin/Sint1). This gene is mapped to human chromosome 17q25.

Immunogène

synthetic peptide of corresponding to the N-terminus of rat Septin 9 conjugated to KLH

Application

Monoclonal Anti-Septin 9 has been used in:
  • immunoblotting
  • immunocytochemistry
  • immunohistochemistry
  • immunofluorescence

Actions biochimiques/physiologiques

Septin 9 (SEPT9) has been implicated in tumorigenesis. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. In addition, SEPT9 is shown to be a DNA methylation-based biomarker, effectively discriminated colorectal cancer from normal specimens.

Forme physique

Solution in 0.01M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Taro Tachibana et al.
Hybridoma (2005), 29(2), 169-171 (2010-05-07)
The septin family of GTPase proteins has been shown to be important for cell division, cytoskeletal organization, and membrane-remodeling events. Septin 9 (SEPT9) is a member of the septin family (also designated MSF/eseptin/Sint1) and has been implicated in tumorigenesis. The
Polarity of neuronal membrane traffic requires sorting of kinesin motor cargo during entry into dendrites by a microtubule-associated septin
Karasmanis EP, et al.
Developmental Cell, 46(2), 204-218 (2018)
Eva P Karasmanis et al.
Current biology : CB, 29(13), 2174-2182 (2019-06-18)
Abscission is the terminal step of mitosis that physically separates two daughter cells [1, 2]. Abscission requires the endocytic sorting complex required for transport (ESCRT), a molecular machinery of multiple subcomplexes (ESCRT-I/II/III) that promotes membrane remodeling and scission [3-5]. Recruitment
AML1 amplification and 17q25 deletion in a case of childhood acute lymphoblastic leukemia
Gulten T, et al.
Journal of Clinical Laboratory Analysis, 23(6), 368-371 (2009)
Detection of methylated SEPT9 in plasma is a reliable screening method for both left-and right-sided colon cancers
Toth K, et al.
PLoS ONE, 7(9), e46000-e46000 (2012)
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