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SAB3300047

Sigma-Aldrich

Monoclonal Anti-TUBB3 antibody produced in mouse

clone 5H2, purified immunoglobulin, buffered aqueous glycerol solution

Synonyme(s) :

Anti-β-4, Anti-MC1R, Anti-TUBB4

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About This Item

Code UNSPSC :
12352203

Source biologique

mouse

Conjugué

unconjugated

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

5H2, monoclonal

Forme

buffered aqueous glycerol solution

Poids mol.

antigen 50.3 kDa

Espèces réactives

human

Technique(s)

western blot: suitable

Numéro d'accès NCBI

NM_006086

Numéro d'accès UniProt

Q13509

Conditions d'expédition

dry ice

Température de stockage

−20°C

Informations sur le gène

human ... TUBB3(10381)

Immunogène

Recombinant protein expressed in E. coli corresponding to amino acids 1-150 of human TUBB3

Description de la cible

Tubulin is the major building block of microtubules. This intracellular cylindrical filamentous structure is present in almost all eukaryotic cells. Microtubules function as structural and mobile elements in mitosis, intracellular transport, flagellar movement, and the cytoskeleton. Except in the simplest eukaryotes, tubulin exists in all cells as a mixture of similar, but not identical, sets of alpha and beta tubulin polypeptides. Within either set of polypeptides, individual subunits diverge from each other (both within and across species) at less than 10% of the amino acid positions. The most extreme diversity is localized to the 15 residues of the carboxy terminal. For β-tubulin five evolutionarily conserved isotype clones have been identified. These are almost totally conserved in the subunits utilized in the same cell types of different species, with the exception of the hematopoietic β-tubulin which is the most highly divergent in sequence and is not conserved between species. Research has been centered around the hypothesis that these beta tubulin isotypes contribute to unique functional properties. It has been reported that the different isotypes of tubulin differ from each other in their ability to polymerize into microtubules.

Forme physique

Solution in phosphate buffered saline containing 1% bovine serum albumin, 50% glycerol, and 0.02% sodium azide.

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Réf. du produit
Description
Tarif

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Emily Palmero et al.
Scientific reports, 6, 39394-39394 (2016-12-20)
In our lab we study neurogenesis and the development of brain tumors. We work towards treatment strategies for glioblastoma and towards using autologous neural stem cells for tissue regeneration strategies for brain damage and neurodegenerative disorders. It has been our
Jessica E M Dunleavy et al.
Development (Cambridge, England), 148(24) (2021-11-26)
Katanin microtubule-severing enzymes are crucial executers of microtubule regulation. Here, we have created an allelic loss-of-function series of the katanin regulatory B-subunit KATNB1 in mice. We reveal that KATNB1 is the master regulator of all katanin enzymatic A-subunits during mammalian

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