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S8197

Sigma-Aldrich

SMER28

>99% (HPLC), solid

Synonyme(s) :

6-bromo-N-2-propenyl-4-quinazolinamine

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About This Item

Formule empirique (notation de Hill):
C11H10BrN3
Numéro CAS:
307538-42-7
Poids moléculaire :
264.12
Numéro MDL:
MFCD02166825
Code UNSPSC :
12352200
ID de substance PubChem :
329824598
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

>99% (HPLC)

Forme

solid

Solubilité

DMSO: >20 mg/mL
H2O: insoluble

Température de stockage

2-8°C

Chaîne SMILES 

Brc1ccc2ncnc(NCC=C)c2c1

InChI

1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15)

Clé InChI

BCPOLXUSCUFDGE-UHFFFAOYSA-N

Application

SMER28 may be used in mTOR-mediated signaling studies.

Actions biochimiques/physiologiques

SMER28 is a small molecule modulator of mammalian autophagy; enhances A53T alpha-synuclein clearance in PC-12 cells independent of rapamycin treatment; appears to act independent of the mTOR pathway, but combined treatment with saturating rapamycin concentration enhances the effect of either compound alone on A53T alpha-synuclein clearance; autophagy inducers may prove useful in the treatment of neurodegenerative and infectious diseases and cancer.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Dee Shen et al.
Cell biochemistry and biophysics, 60(3), 173-185 (2010-12-07)
Aggresomes and related inclusion bodies appear to serve as storage depots for misfolded and aggregated proteins within cells, which can potentially be degraded by the autophagy pathway. A homogenous fluorescence-based assay was devised to detect aggregated proteins inside aggresomes and
Ann K Rosenthal et al.
The Journal of biological chemistry, 290(21), 13028-13038 (2015-04-15)
Chondrocyte-derived extracellular organelles known as articular cartilage vesicles (ACVs) participate in non-classical protein secretion, intercellular communication, and pathologic calcification. Factors affecting ACV formation and release remain poorly characterized; although in some cell types, the generation of extracellular vesicles is associated
Prashant Bharadwaj et al.
Neural regeneration research, 15(10), 1931-1936 (2020-04-05)
Multiple lines of evidence show that soluble oligomer forms of amyloid β protein (Aβ42) are the most neurotoxic species in the brain and correlates with the degree of neuronal loss and cognitive deficit in Alzheimer's disease. Although many studies have
Yu Wu et al.
The FEBS journal, 287(15), 3184-3199 (2020-01-05)
The endo-lysosome system is involved in endocytosis, protein sorting, and degradation as well as autophagy. Numerous toxins and pathogens exploit this system to enter host cells and exert their deleterious effects. Modulation of host endo-lysosome pathway may restrict multiple toxins

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