PZ0158

PF 3845 hydrate

≥98% (HPLC)

• Synonyme(s) : N-3-Pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide hydrate
• Formule empirique (notation de Hill) : C₂₄H₂₃F₃N₄O₂ · xH₂O
• Numéro CAS: 1196109-52-0
• Poids moléculaire : 456.46 (anhydrous basis)
• Numéro MDL: MFCD21365072
• Code UNSPSC : 51111800
• ID de substance PubChem : 329823740
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to tan
• Solubilité: DMSO: ≥45 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: O.FC(F)(F)c1ccc(Oc2cccc(CC3CCN(CC3)C(=O)Nc4cccnc4)c2)nc1
• InChI: 1S/C24H23F3N4O2.H2O/c25-24(26,27)19-6-7-22(29-15-19)33-21-5-1-3-18(14-21)13-17-8-11-31(12-9-17)23(32)30-20-4-2-10-28-16-20;/h1-7,10,14-17H,8-9,11-13H2,(H,30,32);1H2
• Clé InChI: CVQMBUCCSAKASE-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

PF 3845 hydrate is a potent, irreversible FAAH inhibitor

PF 3845 is a potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH), the principle enzyme involved in the degradation of the endocannabinoid anandamide. The endocannabinoid system is a target for therapeutic pain relief. PF-3845 is a covalent inhibitor that carbamylates FAAH′s serine nucleophile. It high selectivity over other enzymes including FAAH-2. In mouse studies, PF-3845 has been shown to raise brain anandamide levels for up to 24 hr; and in a rat model it produced significant reduction of inflammatory pain..

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable