M8515

Monastrol

≥98% (HPLC), solid

• Synonyme(s) : 4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester
• Formule empirique (notation de Hill) : C₁₄H₁₆N₂O₃S
• Numéro CAS: 254753-54-3
• Poids moléculaire : 292.35
• Numéro MDL: MFCD00813077
• Code UNSPSC : 12352200
• ID de substance PubChem : 24897267
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Conditions de stockage: protect from light
• Couleur: white to off-white
• Pf: 185-185.9 °C (lit.)
• Solubilité: DMSO: >5 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: CCOC(=O)C1=C(C)NC(=S)NC1c2cccc(O)c2
• InChI: 1S/C14H16N2O3S/c1-3-19-13(18)11-8(2)15-14(20)16-12(11)9-5-4-6-10(17)7-9/h4-7,12,17H,3H2,1-2H3,(H2,15,16,20)
• Clé InChI: LOBCDGHHHHGHFA-UHFFFAOYSA-N

Description

Application

Monastrol has been used:

• to treat MDA-MB-231 cells as a non-microtubule-targeting agent[1]
• as a antineoplastic agent, to treat mouse myeloma cell line SP 2/0, to induce apoptosis and to elucidate the role of metabotropic glutamate receptor 3 (Grm3) in apoptosis[2]
• as an inhibitor of pteridine reductase in GFP-transfected promastigotes infected macrophages for flow cytometer-based growth inhibition assay and to evaluate anti-leishmanial activity of Leishmania donovani hamster model in vivo[3]

Actions biochimiques/physiologiques

Monastrol is a potent, cell-permeant inhibitor of mitosis. Monastrol arrested cells are characterized by monopolar spindles. This phenotype is induced through specific disruption of mitotic molecular motor kinesin Eg5 with IC₅₀ at 14 μM. No effect on other motor proteins and tubulin.

Caractéristiques et avantages

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Conditionnement

Packaged under inert gas.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)