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K8625

Sigma-Aldrich

L-Kynurenine

≥98% (HPLC)

Synonyme(s) :

β-Anthraniloyl-L-alanine, L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

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25 MG
55,00 €
100 MG
189,00 €
500 MG
545,00 €
1 G
937,00 €

About This Item

Formule empirique (notation de Hill):
C10H12N2O3
Numéro CAS:
Poids moléculaire :
208.21
Numéro MDL:
Code UNSPSC :
12352209
ID de substance PubChem :
Nomenclature NACRES :
NA.26

55,00 €


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Nom du produit

L-Kynurenine, ≥98% (HPLC)

Niveau de qualité

Essai

≥98% (HPLC)

Forme

powder

Pf

219 °C

Application(s)

detection

Chaîne SMILES 

N[C@@H](CC(=O)c1ccccc1N)C(O)=O

InChI

1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1

Clé InChI

YGPSJZOEDVAXAB-QMMMGPOBSA-N

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Application

L-Kynurenine has been used as a standard for indoleamine-2,3-dioxygenase (IDO) assay.[1] It has also been used as a standard to extract and quantify kynurenine from cultured cells and media.[2]

Actions biochimiques/physiologiques

L-Kynurenine is a key intermediate in the breakdown of L-tryptophan[3] and the formation of nicotinamide adenine dinucleotide (NAD+) via the kynurenine pathway. It is involved in a variety of neurological processes and diseases.[4][5] L-Kynurenine is a substrate for kynureninase/kynurenine hydrolase; kynurenine 3-monooxygenase and kynurenine-oxoglutarate transaminase.
Key intermediate in the breakdown pathway of tryptophan.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)


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Certificats d'analyse (COA)

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Essential and Non-Essential Metals Metabolites with Antibiotic Activity Pharmacology of Benzodiazepines Interferon Gamma Research (2012)
Kimberley Kolijn et al.
Cancer research, 78(16), 4671-4679 (2018-06-21)
Cancer invasion and metastasis are driven by epithelial-mesenchymal transition (EMT), yet the exact mechanisms that account for EMT in clinical prostate cancer are not fully understood. Expression of N-cadherin is considered a hallmark of EMT in clinical prostate cancer. In
Evaluation of radiofluorinated carboximidamides as potential IDO-targeted PET tracers for cancer imaging
Xuan Huang
Oncotarget, 8(29), 46900-46914 (2017)
Extraction and Quantification of Tryptophan and Kynurenine from Cultured Cells and Media Using a High Performance Liquid Chromatography (HPLC) System Equipped with an Ultra-Sensitive Diode Array Detector
Jeffrey Kim
Bio-protocol, 6(7), e1781-e1781 (2016)
Cara C Schafer et al.
Oncotarget, 7(46), 75407-75424 (2016-10-06)
Indoleamine 2,3-dioxygenase (IDO) has been implicated in immune evasion by tumors. Upregulation of this tryptophan (Trp)-catabolizing enzyme, in tumor cells and myeloid-derived suppressor cells (MDSCs) within the tumor microenvironment (TME), leads to Trp depletion that impairs cytotoxic T cell responses

Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. Ist gelöstes Kynurenine bei -20°C haltbar und wenn ja wie lang?

    1 answer
    1. The stability of the solution at -20 °C is not determined. Upon resuspension of L-Kynurenine, it is recommended to store solutions at 15-25 °C. The resuspended product is stable for 6 months when properly stored. It is also recommended to protect this product from light.

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