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H7166

Sigma-Aldrich

Interleukin-3 human

IL-3, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture

Synonyme(s) :

IL-3

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About This Item

Numéro MDL:
MFCD00147276
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.77

Source biologique

human

Niveau de qualité

100

Produit recombinant

expressed in HEK 293 cells

Pureté

>95% (SDS-PAGE)

Forme

lyophilized powder

Puissance

≤2 ng/mL EC50

Qualité

endotoxin tested

Poids mol.

dimer 17-45 kDa (glycosylated)

Conditionnement

pkg of 10 μg

Fabricant/nom de marque

HumanZyme

Technique(s)

cell culture | mammalian: suitable

Impuretés

<1 EU/μg

Numéro d'accès UniProt

P08700

Température de stockage

−20°C

Informations sur le gène

human ... IL3(3562)

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Catégories apparentées

Actions biochimiques/physiologiques

Interleukin-3 (IL-3) is a multifunctional protein, originally called colony forming unit-stimulating activity (CFU-SA), and is produced by activated T lymphocytes. IL-3 supports the formation of multilineage colonies in the early development of multipotent hematopoietic progenitor cells. IL-3 has been shown to induce colony formation of macrophages, neutrophils, mast cells, and megakaryocytes from agar-suspended bone marrow cells. IL-3 also interacts with IL-2 to stimulate growth of T lymphocytes and to induce IgG secretion from activated B cells. Other synonyms for IL-3 include pan-specific hemopoietin, multicolony stimulating factor, mast cell growth factor, burst promoting activity, histamine-producing cell stimulating factor, P cell stimulating factor, and WEHI-3 factor.

Forme physique

Lyophilized from a 0.2 μm filtered solution of 1x PBS.

Notes préparatoires

HumanKine Interleukin-3 (IL-3), expressed in human HEK 293 cells, is a glycosylated monomer with an apparent molecular mass of 17-45 kDa due to glycosylation, which is absent when this cytokine is expressed in E. coli. Production in human HEK 293 cells offers authentic glycosylation which contributes to stability in cell growth media and other applications.

Remarque sur l'analyse

The activity was determined by the dosedependent stimulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).

Informations légales

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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