H4791
Bone Morphogenetic Protein 2 human
BMP-2, recombinant, expressed in HEK 293 cells, HumanKine, suitable for cell culture
Synonyme(s) :
BMP-2
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About This Item
Produits recommandés
Source biologique
human
Niveau de qualité
Produit recombinant
expressed in HEK 293 cells
Forme
lyophilized powder
Puissance
≤60 ng/mL EC50
Qualité
endotoxin tested
Poids mol.
dimer 30-38 kDa (glycosylated)
Conditionnement
pkg of 10 μg
Conditions de stockage
avoid repeated freeze/thaw cycles
Technique(s)
cell culture | mammalian: suitable
Impuretés
≤1 EU/μg Endotoxin level
Numéro d'accès UniProt
Température de stockage
−20°C
Informations sur le gène
human ... BMP2(650)
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Description générale
Bone Morphogenetic Protein 2 is a member of the TGF-β superfamily of cytokines that affect bone and cartilage formation. It is important for skeletal development during embryogenesis. BMP-2 induces chondrocyte formation, osteoblast differentiation, and is involved in embryo dorsal-ventral patterning and organogenesis.
Actions biochimiques/physiologiques
It has been reported that Bone Morphogenetic Protein 2 (BMP-2) inhibits estradiol induced proliferation of human breast cancer cells. BMP-2 signaling mediates apoptosis by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. Cellular responses to BMP-2 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors, which play significant roles in BMP binding and signaling. One BMP type II receptor and two BMP type I receptors have been identified. Both BMP type I receptors bind BMP-2 with high-affinity in the absence of BMP receptor type II.
Forme physique
Lyophilized from a 0.2 μm filtered solution of 2x PBS + 6% Ethanol.
Notes préparatoires
This Bone Morphogenetic Protein 2 (BMP-2) is produced from a DNA sequence encoding the human BMP-2 protein, expressed in HEK 293 cells. It is a glycosylated homodimer linked by a single disulfide bond with an apparent molecular mass of 30-38 kDa.
Remarque sur l'analyse
The specific activity was determined by its ability to induce alkaline phosphatase production in a dose response to BMP-2 in the ATDC-5 cell line (mouse chondrogenic cell line).
Informations légales
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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