F133

Norfluoxetine hydrochloride

≥97%, solid

• Synonyme(s) : (±)-γ-(4-Trifluoromethylphenoxy)benzenepropanamine hydrochloride
• Formule empirique (notation de Hill): C₁₆H₁₆F₃NO · HCl
• Numéro CAS: 57226-68-3
• Poids moléculaire : 331.76
• Numéro MDL: MFCD01321043
• Code UNSPSC : 12352200
• ID de substance PubChem : 24894760
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥97%
• Forme: solid
• Couleur: yellow
• Solubilité: H₂O: >4 mg/mL; DMSO: >5 mg/mL
• Chaîne SMILES: Cl[H].NCCC(Oc1ccc(cc1)C(F)(F)F)c2ccccc2
• InChI: 1S/C16H16F3NO.ClH/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12;/h1-9,15H,10-11,20H2;1H
• Clé InChI: GMTWWEPBGGXBTO-UHFFFAOYSA-N

Description

Application

Norfluoxetine hydrochloride has been used to examine if psychoactive pharmaceuticals in drinking water at environmental concentrations could induce neuronal gene expression. It has also been used to examine whether at environmental concentrations it can alter in vitro expression of autism spectrum disorders (ASD)-associated synaptic proteins in human neurons.

Actions biochimiques/physiologiques

Fluoxetine metabolite; more potent inhibitor of serotonin uptake than fluoxetine with a half-life in vivo of 5-7 days.

Norfluoxetine is an active metabolite of fluoxetine. It disturbs the production of estrogen in a co-culture model of the feto-placental unit.

Attention

Hygroscopic, photosensitive

Informations légales

Sold under license from Eli Lilly and Company.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)