Accéder au contenu
Merck
Toutes les photos(2)

Principaux documents

Voir toute la documentation

E3520

Sigma-Aldrich

Ebselen

powder, ≥98% (TLC)

Synonyme(s) :

2-Phenyl-1,2-benzisoselenazol-3(2H)-one

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme

Sélectionner une taille de conditionnement

25 MG
292,00 €
100 MG
628,00 €

292,00 €

Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit.
Devis pour commande en gros
Toutes les photos(2)

Sélectionner une taille de conditionnement

Changer de vue
25 MG
292,00 €
100 MG
628,00 €

About This Item

Formule empirique (notation de Hill):
C13H9NOSe
Numéro CAS:
60940-34-3
Poids moléculaire :
274.18
Numéro MDL:
MFCD00210937
Code UNSPSC :
12352202
ID de substance PubChem :
24278417
Nomenclature NACRES :
NA.77

292,00 €

Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit.
Devis pour commande en gros

Nom du produit

Ebselen, cysteine modifier

Niveau de qualité

200

Essai

≥98% (TLC)

Forme

powder

Pf

176-182  °C

Solubilité

chloroform: 19.60-20.40 mg/mL, clear, yellow

Température de stockage

2-8°C

Chaîne SMILES 

O=C1N([Se]c2ccccc12)c3ccccc3

InChI

1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H

Clé InChI

DYEFUKCXAQOFHX-UHFFFAOYSA-N

Vous recherchez des produits similaires ? Visite Guide de comparaison des produits

Description générale

Ebselen is a sympathomimetic amine.[1]

Application

Ebselen has been used as a:
  • voltage-dependent calcium channels (VDCCs) blocker[2]
  • glutathione peroxidase mimetic to test its inhibitory effect on contraction-mediated deoxy glucose (2-DG) uptake in mouse

extensor digitorum longus (fast-twitch) muscle[3]
  • glucocerebrosidase inhibitor[1]
  • hepatitis C virus helicase inhibitor[4]

Actions biochimiques/physiologiques

An organo-selenium compound possessing antioxidant properties. Inhibits mammalian lipoxygenases in the absence of thiol groups, and glutathione S-transferase and papain via the interaction with cysteine residues. Also inhibits indoleamine 2,3-dioxygenase by covalently modifying a cysteine residue, the effect being reversible with dithiothreitol.[5] Inhibits oxidation of low density lipoproteins (LDL).
Ebselen, a glutathione-peroxidase-mimic, elicits anti-inflammatory activity.[1] It also has anti-atherosclerotic functionality. Ebselen displays antibacterial action on) multidrug-resistant Staphylococcus aureus (MRSA) infections and could be a potential therapeutic target for treating MRSA based skin infection.[6] It is regarded as neuroprotective agent and elicits chemopreventive functionality in inflammation-associated carcinogenesis.[7]

Pictogrammes

Skull and crossbonesHealth hazardEnvironment
GHS06,GHS08,GHS09

Mention d'avertissement

Danger

Mentions de danger

H301 + H331,H373,H410

Classification des risques

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

Code de la classe de stockage

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
0000384459
0000384459
0000334537
0000195888
0000161739

Vous ne trouvez pas la bonne version ?

Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.

Rechercher un(e) COA

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Les clients ont également consulté

Slide 1 of 6

1 of 6

MnTBAP Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger.

Sigma-Aldrich

475870

MnTBAP

DL-α-Tocopherol succinate BioXtra, ≥98.0% (HPLC)

Sigma-Aldrich

95255

DL-α-Tocopherol succinate

TDZD-8 ≥98% (HPLC), needles

Sigma-Aldrich

T8325

TDZD-8

Selenomethionine United States Pharmacopeia (USP) Reference Standard

USP

1611955

Selenomethionine

Seleno-L-cystine 95%

Sigma-Aldrich

545996

Seleno-L-cystine

Xanthine Oxidase, Buttermilk Native xanthine oxidase from buttermilk. Complex metalloprotein that catalyzes oxidative hydroxylation of a variety of aromatic heterocycles and simple aldehydes. Catalyzes the oxidation of xanthine to uric acid.

Sigma-Aldrich

682151

Xanthine Oxidase, Buttermilk

Diana Islam et al.
American journal of respiratory and critical care medicine, 199(10), 1214-1224 (2018-12-07)
Rationale: There are controversial reports on applications of mesenchymal stromal cells (MSCs) in patients with acute respiratory distress syndrome (ARDS). Objectives: We hypothesized that lung microenvironment was the main determinant of beneficial versus detrimental effects of MSCs during ARDS. Methods:
Chuanjiang Dong et al.
Frontiers in microbiology, 10, 3016-3016 (2020-02-06)
As a thiol-dependent enzyme, thioredoxin reductase (TrxR) is a promising antibacterial drug target. Ebselen, an organo-selenium with well-characterized toxicology and pharmacology, was recently reported to have potent antibacterial activity against Staphylococcus aureus. In this paper, we demonstrated that ebselen has
Selcuk Yatmaz et al.
American journal of respiratory cell and molecular biology, 48(1), 17-26 (2012-09-25)
Oxidative stress caused by excessive reactive oxygen species production is implicated in influenza A virus-induced lung disease. Glutathione peroxidase (GPx)-1 is an antioxidant enzyme that may protect lungs from such damage. The objective of this study was to determine if
Andrew C Terentis et al.
Biochemistry, 49(3), 591-600 (2009-12-17)
The heme enzyme indoleamine 2,3-dioxygenase (IDO) plays an important immune regulatory role by catalyzing the oxidative degradation of l-tryptophan. Here we show that the selenezal drug ebselen is a potent IDO inhibitor. Exposure of human macrophages to ebselen inhibited IDO
N Noguchi et al.
Biochimica et biophysica acta, 1213(2), 176-182 (1994-07-14)
The oxidative modification of low density lipoprotein (LDL) is accepted to be an important early event of atherosclerosis, but it has not yet been well understood. The preventive effects of two antioxidants with different functions, ebselen and probucol, against the
Afficher tous les articles scientifiques apparentés

Articles

Papain, Cysteine Protease, Properties & Products

Uncover properties and applications of the cysteine protease papain and find inhibitors, substrates, and other papain products.

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

Questions

Reviews

No rating value

Active Filters

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique