D8668

2′-Deoxyadenosine monohydrate

powder, BioReagent, suitable for cell culture

• Synonyme(s) : 9-(2-Deoxy-β-D-ribofuranosyl)adenine, Adenine deoxyriboside
• Formule empirique (notation de Hill): C₁₀H₁₃N₅O₃ · H₂O
• Numéro CAS: 16373-93-6
• Poids moléculaire : 269.26
• Numéro Beilstein : 91015
• Numéro CE : 213-488-7
• Numéro MDL: MFCD00005754
• Code UNSPSC : 12352207
• ID de substance PubChem : 24894112
• Nomenclature NACRES : NA.75

Propriétés

• Source biologique: synthetic (organic)
• Gamme de produits: BioReagent
• Pureté: ≥99% (HPLC)
• Forme: powder
• Technique(s): cell culture | mammalian: suitable
• Solubilité: H₂O: soluble 25 mg/mL, clear to slightly hazy, colorless to faintly yellow
• Température de stockage: 2-8°C
• Chaîne SMILES: [H]O[H].Nc1ncnc2n(cnc12)[C@H]3C[C@H](O)[C@@H](CO)O3
• InChI: 1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1
• Clé InChI: OLXZPDWKRNYJJZ-RRKCRQDMSA-N

Description

Application

2′-Deoxyadenosine monohydrate has been used as a nucleotide precursor:

• To study the importance of homologous recombination at the interface between replication and mitosis
• To analyze deoxynucleoside-assisted transductions
• To study the effect of increased deoxycytidine on gemcitabine resistance in pancreatic cancer cells

2′-Deoxyadenosine monohydrate has been used for the preparation of deoxyribonucleoside stock solution for the anaerobic culture of Bacillus mojavensis strains including JF-2 and two Bacillus subtilis strains.

Actions biochimiques/physiologiques

Excess 2′-deoxyadenosine gets converted to adenosine triphosphate (dATP), which inhibits ribonucleotide reductase.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves