C4780

Coenzyme A sodium salt hydrate

BioReagent, suitable for cell culture

• Synonyme(s) : CoA Na₂
• Formule empirique (notation de Hill): C₂₁H₃₆N₇O₁₆P₃S · xNa⁺ · yH₂O
• Numéro CAS: 55672-92-9
• Poids moléculaire : 767.53 (anhydrous free acid basis)
• Numéro CE : 259-747-8
• Numéro MDL: MFCD00079020
• Code UNSPSC : 12352205
• ID de substance PubChem : 24892723
• Nomenclature NACRES : NA.75

Propriétés

• Source biologique: yeast
• Niveau de qualité: 200
• Description: cofactor for acyl transfer
• Gamme de produits: BioReagent
• Essai: ≥85% (HPLC)
• Forme: powder
• Technique(s): cell culture | mammalian: suitable
• Solubilité: water: 50 mg/mL, clear, colorless to faintly yellow
• Température de stockage: −20°C
• Chaîne SMILES: [Na+].CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
• InChI: 1S/C21H36N7O16P3S.Na/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H
• Clé InChI: SYTRWOCXZXQBPW-CLVRNSBASA-M

Description

Application

Coenzyme A sodium salt hydrate has been used:

• in the branch chain aminotransferase enzymatic assay and protein determination
• in the assay for halogenation of pyrrolyl-S-Bmp1 (an acyl carrier protein (ACP)-thioesterase (TE) di-domain protein) by Bmp2
• as an extracellular coenzyme A (CoA) in in vitro and in vivo experiments to study alternative routes by which cells and organisms can obtain CoA

Actions biochimiques/physiologiques

Coenzyme A (CoA) is a ubiquitous cofactor that plays an important role in many metabolic pathways, mainly as acyl-CoA. It is essential for the tricarboxylic acid cycle, and the synthesis and oxidation of fatty acids. CoA facilitates acyl group transfers, especially in fatty acid and lipid metabolism reactions. It is associated with neurodegeneration, autophagy, protein acetylation, and signal transduction.

Qualité

Enzymatically assayed using phosphotransacetylase. Approx. 95% CoA-SH

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)