Pentagastrin is subject to oxidation in solution. A pentagastrin solution in DMF can be stored frozen to protect the TRP and MET from oxidation. Further protection from oxidation can be insured if the solution is prepared with degassed solvent and the solution is stored under an inert gas such as argon or dry nitrogen gas.
B1636
Pentagastrin
≥95% (HPLC), powder, CCK2 receptor agonist
Synonyme(s) :
Peptavlon, Petogasrin, N-t-Boc-β-Ala-Trp-Met-Asp-Phe amide
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25 MG
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687,00 €
About This Item
Formule empirique (notation de Hill) :
C37H49N7O9S
Numéro CAS:
Poids moléculaire :
767.89
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352200
ID de substance PubChem :
Nomenclature NACRES :
NA.77
207,00 €
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Nom du produit
Pentagastrin, ≥95% (HPLC), powder
Essai
≥95% (HPLC)
Forme
powder
Conditions de stockage
(Keep container tightly closed in a dry and well-ventilated place.)
Couleur
white to off-white
Solubilité
DMF: 20 mg/mL, clear, colorless to faint yellow or tan
Température de stockage
−20°C
Chaîne SMILES
CSCCC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)NC(CC(O)=O)C(=O)NC(Cc3ccccc3)C(N)=O
InChI
1S/C37H49N7O9S/c1-37(2,3)53-36(52)39-16-14-30(45)41-28(19-23-21-40-25-13-9-8-12-24(23)25)34(50)42-26(15-17-54-4)33(49)44-29(20-31(46)47)35(51)43-27(32(38)48)18-22-10-6-5-7-11-22/h5-13,21,26-29,40H,14-20H2,1-4H3,(H2,38,48)(H,39,52)(H,41,45)(H,42,50)(H,43,51)(H,44,49)(H,46,47)
Clé InChI
NEYNJQRKHLUJRU-UHFFFAOYSA-N
Informations sur le gène
mouse ... Cckbr(12426)
rat ... Cckar(24889) , Cckbr(25706)
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Amino Acid Sequence
Boc-Bal-Trp-Met-Asp-Phe-NH2
Description générale
Research area: Immunology & cytokines
Application
Pentagastrin has been used to bidirectionally modulate lateral nucleus of the amygdala (LA) activity.[1] It has also been used as a cholecystokinin-2 receptor (CCK2R) agonist to block the receptor binding for Ga-DOTA-MGS5 in AR42J rat pancreatic cell lines during cell uptake and receptor binding studies.[2]
Actions biochimiques/physiologiques
Pentagastrin, a synthetic polypeptide is a gastrin analog. It contains the five C-terminal amino acids of gastrin.[3] It acts as a cholecystokinin-2 (CCK2) receptor/ cholecystokinin-B (CCKB) receptor agonist.[4] Pentagastrin stimulates the secretion of pepsin and gastric acid.[3] It also aids in the evaluation of gastric acid secretory function.[5] Pentagastrin exhibits panicogenic/ anxiogenic effects and thereby induces panic attacks in panic disorder (PD) patients.[4]
Anticorps
Inhibiteur
Réf. du produit
Description
Tarif
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Certificats d'analyse (COA)
Lot/Batch Number
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Anton A Hörmann et al.
Pharmaceuticals (Basel, Switzerland), 14(6) (2021-07-03)
The new minigastrin analog DOTA-MGS5 is a promising new candidate for targeting cholecystokinin-2 receptor (CCK2R)-expressing tumors. To enable the clinical translation of PET/CT imaging using 68Ga-labeled DOTA-MGS5, different quality and safety aspects need to be considered to comply with the
Géraldine Pina et al.
Clinical endocrinology, 78(3), 358-364 (2012-08-24)
To evaluate a second-generation assay for basal serum calcitonin (CT) measurements compared with the pentagastrin-stimulation test for the diagnosis of inherited medullary thyroid carcinoma (MTC) and the follow-up of patients with MTC after surgery. Recent American Thyroid Association recommendations suggest
Gilbert H Daniels
Thyroid : official journal of the American Thyroid Association, 21(11), 1199-1207 (2011-09-23)
Medullary thyroid carcinoma (MTC) is a rare thyroid malignancy with the potential for aggressive behavior. Measurement of serum calcitonin (Ct) in the thyroid nodule population is the most sensitive way to detect occult MTC. An important and controversial question is
Pentagastrin as a stimulant in routine clinical testing of gastric acid secretion.
S A Pedersen
Digestion, 3(2), 81-89 (1970-01-01)
Functional, Diagnostic and Therapeutic Aspects of Gastrointestinal Hormones
Ahmed M and Ahmed S
Gastroenterology Research and Practice, 233-244 (2019)
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How can Pentagastrin, Product B1636, solutions be stored?
1 answer-
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the shelf-life of Pentagastrin, Product B1636?
1 answer-
This product does not have any official shelf-life or expiration dating associated with it. The only date shown on the certificate of analysis will be the QC Release date. For customers whose systems require formal date management, use of a date one year from shipment is supported by our terms and conditions of supply.
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What is Pentagastrin, Product B1636, soluble in?
1 answer-
Pentagastrin is soluble in either dimethylformamide (DMF) or DMSO at a concentration of 20 mg/mL.
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