676764

Tetrahydrofurane

≥99.0%, ACS reagent, contains 250 ppm BHT as inhibitor, suitable for HPLC

• Synonyme(s) : Oxolane, Oxyde de butylène, Oxyde de tétraméthylène
• Formule empirique (notation de Hill): C₄H₈O
• Numéro CAS: 109-99-9
• Poids moléculaire : 72.11
• Numéro Beilstein : 102391
• Numéro CE : 203-726-8
• Numéro MDL: MFCD00005356
• Code UNSPSC : 12191501
• ID de substance PubChem : 329760651
• Nomenclature NACRES : NA.07

Propriétés

• product name: Tetrahydrofurane, ACS reagent, ≥99.0%, contains 250 ppm BHT as inhibitor
• Qualité: ACS reagent
• Densité de vapeur: 2.5 (vs air)
• Pression de vapeur: 114 mmHg ( 15 °C); 143 mmHg ( 20 °C)
• Pureté: ≥99.0%
• Forme: liquid
• Température d'inflammation spontanée: 610 °F
• Contient: 250 ppm BHT as inhibitor
• Limite d'explosivité: 1.8-11.8 %
• Technique(s): HPLC: suitable
• Impuretés: ≤0.015% peroxide (as H₂O₂); ≤0.05% water
• Résidus d'évap.: ≤0.03%
• Couleur: APHA: ≤20
• Indice de réfraction: n20/D 1.407 (lit.)
• pH: ~7
• Point d'ébullition: 65-67 °C (lit.)
• Pf: −108 °C (lit.)
• Densité: 0.889 g/mL at 25 °C (lit.)
• Chaîne SMILES: C1CCOC1
• InChI: 1S/C4H8O/c1-2-4-5-3-1/h1-4H2
• Clé InChI: WYURNTSHIVDZCO-UHFFFAOYSA-N

Description

Description générale

Tetrahydrofuran (THF) is a heterocyclic compound (cyclic ether). It is colorless, has low viscosity, and good solubility in a wide range of solvents. It is widely used as a solvent in organic synthesis, being very popular in reactions with organometallic compounds and Grignard reagents. Due to organic peroxides formation on long term storage, THF is usually stabilized by adding butylated hydroxytoluene (BHT). BHT removes the free radicals required for the peroxide formation.

Application

Tetrahydrofuran (THF) is used as a solvent in the following processes:

• Organic synthesis

a) Grignard
b) Organometallic compounds
c) Reformatsky
d) Lithiation
e) Hydride reduction
f) Metal-catalyzed coupling (Heck, Stile, Suzuki)
g) Lewis acid mediated reactions

• Crystallization
• Polymerization. Ex. RAFT (Reversible Addition-Fragmentation Chain Transfer) polymerization of p-acetoxystyrene
• Coatings
• As an O-donor ligand to form coordination complexes
• As mobile phase solvent in high-performance liquid chromatography

Caractéristiques et avantages

ACS solvents meet or exceed the high standards of the American Chemical Society (ACS) ,with test specifications that are specialized to every compound. According to the American Chemical Society, ACS reagent grade implies that it is a substance of sufficient purity to be used in most chemical analyses or reactions.

Autres remarques

Go to our Greener Alternative-2-Methyl Tetrahydrofuran - 155810

Go to our Greener Alternative-Cyclopentyl methylether - 675989

Informations sur la sécurité

• Pictogrammes: GHS02,GHS08,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H225,H302,H319,H335,H336,H351
• Conseils de prudence: P202 - P210 - P233 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Risques supp: EUH019
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): -6.2 °F - closed cup
• Point d'éclair (°C): -21.2 °C - closed cup