PHR1045

Diethylene glycol

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonyme(s) : 2,2′-oxydiéthanol, 2-hydroxyéthyl éther
• Formule linéaire : (HOCH₂CH₂)₂O
• Numéro CAS: 111-46-6
• Poids moléculaire : 106.12
• Beilstein: 969209
• Numéro CE : 203-872-2
• Numéro MDL: MFCD00002882
• Code UNSPSC : 41116107
• ID de substance PubChem : 329823075
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material; pharmaceutical secondary standard
• Niveau de qualité: 300
• Agence: traceable to Ph. Eur. Y0000217; traceable to USP 1193265
• Densité de vapeur: 2.14 (vs air)
• Pression de vapeur: 0.01 mmHg ( 20 °C)
• Famille d'API: diethylene glycol
• CofA (certificat d'analyse): current certificate can be downloaded
• Température d'inflammation spontanée: 442 °F
• Limite d'explosivité: 2-12.3 %
• Technique(s): HPLC: suitable; gas chromatography (GC): suitable
• Indice de réfraction: n20/D 1.447 (lit.)
• pb: 245 °C (lit.)
• Pf: −10 °C (lit.)
• Densité: 1.118 g/mL at 25 °C (lit.)
• Application(s): cleaning products; cosmetics; food and beverages; personal care; pharmaceutical (small molecule)
• Format: neat
• Température de stockage: 2-30°C
• Chaîne SMILES: OCCOCCO
• InChI: 1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2
• Clé InChI: MTHSVFCYNBDYFN-UHFFFAOYSA-N

Description

Description générale

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Diethylene glycol is a a four carbon dimer of ethylene glycol[1] and finds applications as antifreeze, solvent, humectant, hydraulic fluid and brake fluid. It is a potential neuro- and nephrotoxin for humans. It may also be utilized in moisturizers, lubricants, emulsification agents, additives and solvents.[2]

Application

Diethylene glycol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography (HPLC). [2]

Diethylene glycol may be used as a standard in the determination of diethylene glycol present in serum samples using gas chromatography (GC).[3] It may also be used as a reference standard in validating the composition of diethylene glycol in propolis syrup consumed by intoxicated victims using nuclear magnetic resonance studies (NMR) and gas chromatography coupled with flame ionization detector (GC-FID).[4]

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Remarque sur l'analyse

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Autres remarques

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Note de bas de page

To see an example of a Certificate of Analysis for this material enter LRAC0277 in the slot below. This is an example certificate only and may not be the lot that you receive.

Produits recommandés

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 280.4 °F - closed cup
• Point d'éclair (°C): 138 °C - closed cup