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A3766

Supelco

Antazoline phosphate salt

analytical standard, for drug analysis

Synonyme(s) :

2-(N-Benzylanilinomethyl)-2-imidazoline

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About This Item

Formule linéaire :
C17H19N3 · H3PO4
Numéro CAS:
154-68-7
Poids moléculaire :
363.35
Numéro CE :
205-831-4
Numéro MDL:
MFCD00054317
Code UNSPSC :
41116107
ID de substance PubChem :
329770846
Nomenclature NACRES :
NA.24

Qualité

analytical standard, for drug analysis

Niveau de qualité

200

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

Format

neat

Chaîne SMILES 

OP(O)(O)=O.C1CN=C(CN(Cc2ccccc2)c3ccccc3)N1

InChI

1S/C17H19N3.H3O4P/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16;1-5(2,3)4/h1-10H,11-14H2,(H,18,19);(H3,1,2,3,4)

Clé InChI

DUIGUKRYYAGJAF-UHFFFAOYSA-N

Informations sur le gène

human ... HRH1(3269)

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Actions biochimiques/physiologiques

Imidazoline agonist; more potent than efaroxan in inducing insulin release from β cells; H1 histamine receptor antagonist.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Classification des risques

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
037H0834
087F7703

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

D Berdeu et al.
European journal of pharmacology, 324(2-3), 233-239 (1997-04-18)
In vivo effects of an imidazoline devoid of alpha2-adrenoceptor antagonistic properties, antazoline, on insulin secretion and glycemia were investigated both in fasted rats and dogs. In both species, antazoline (1.5 mg/kg i.v.) transiently increased insulinemia without affecting basal plasma glucose
D Berdeu et al.
European journal of pharmacology, 275(1), 91-98 (1995-02-24)
The relative potencies of imidazoline compounds to induce insulin secretion and vascular resistance were compared in the isolated perfused rat pancreas. On insulin secretion, only the two imidazolines, antazoline and efaroxan, induced a concentration-dependent response, antazoline being 10 times more
R Wertheimer et al.
Klinische Monatsblatter fur Augenheilkunde, 210(2), 93-96 (1997-02-01)
Allergic conjunctivitis is one of the most frequent allergic diseases of the anterior eye segment. This multicentre, clinical trial was an investigation to compare the antiallergic efficacy, local tolerance and safety of Antazolin/Tetryzolin eye drops and Levocabastine eye drops. 69
D Berdeu et al.
European journal of pharmacology, 254(1-2), 119-125 (1994-03-11)
The effects of imidazolines and derivatives were studied on insulin secretion and vascular resistance in the isolated perfused rat pancreas. On insulin secretion, two imidazoline alpha 2-adrenoceptor antagonists, efaroxan (1-100 microM) and RX821002 (10 microM), had a stimulating response; however
M Mourtada et al.
Naunyn-Schmiedeberg's archives of pharmacology, 361(2), 146-154 (2000-02-24)
Pancreatic beta-cells express imidazoline binding sites which play a role in the regulation of insulin secretion, but it is not known whether ligands for these sites also affect other aspects of beta-cell physiology. In the present study, we have investigated
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