AB9744

Anti-14-3-3 τ (tau) Antibody

serum, Chemicon^®

• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Forme d'anticorps: serum
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Espèces réactives: rabbit, rat, bovine, sheep, mouse, human, chicken
• Fabricant/nom de marque: Chemicon^®
• Technique(s): ELISA: suitable; immunohistochemistry: suitable; western blot: suitable
• Numéro d'accès NCBI: NM_006826.2
• Numéro d'accès UniProt: P27348
• Conditions d'expédition: dry ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... YWHAQ(10971)

Description

Description générale

Mammals express seven distinct 14-3-3 isoforms (gamma, epsilon, beta, zeta, sigma, theta, tau) that form multiple homo- and hetero- dimmers, thus rendering 14-3-3 as a key multifunctional regulatory molecule. 14-3-3 isomers have been implicated in several neurological disorders: for example isoforms gamma, epsilon and beta are expressed in the cerebrospinal fluid of Creutzfeldt-Jakob patients, but not patients suffering from other neurological conditions such as Alzheimer′s.

The 14-3-3 tau antibody is one of a panel of antibodies that were generated against 14-3-3 isoforms and have demonstrated their potential for use as an ELISA-based diagnostic tool. These antibodies will allow the research to investigate the role of this protein in key cellular processes and neurological disorders such as Creutzfeldt-Jakob, Alzheimer′s and Parkinson′s Disease.

Spécificité

14-3-3 tau (theta). By Western blot the antibody recognizes the ~30 kDa protein.

Immunogène

Synthetic peptide from the N-terminal area of sheep 14-3-3 tau.

Application

Detect 14-3-3 τ (tau) using this Anti-14-3-3 τ (tau) Antibody validated for use in ELISA, WB, IH.

Western blot: 1:3,000 using ECL.
Immunohistochemistry: 1:30-1:60 on mouse brain tissue which was treated by hydrated autoclaving at 121°C for 15 minutes prior to immunolabeling. Endogenous peroxidase was blocked with hydrogen peroxide in methanol and non-specific labeling with normal goat serum at 1:20 for 5 minutes.
ELISA
Optimal working dilutions must be determined by end user.

Description de la cible

30 kDa

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable