8.51200

DOTA-tris(tert-butyl ester)

Novabiochem^®

• Synonyme(s) : DOTA-tris(tert-butyl ester), Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate
• Formule empirique (notation de Hill): C₂₈H₅₂N₄O₈
• Numéro CAS: 137076-54-1
• Poids moléculaire : 572.73
• Numéro MDL: MFCD02259697
• Code UNSPSC : 12352108

Propriétés

• Niveau de qualité: 200
• Gamme de produits: Novabiochem^®
• Forme: powder
• Pertinence de la réaction: reagent type: fluorescent-labelling reagent
• Fabricant/nom de marque: Novabiochem^®
• Pf: 88-93 °C
• Application(s): peptide synthesis
• Température de stockage: 2-8°C
• InChI: 1S/C28H52N4O8/c1-26(2,3)38-23(35)19-30-12-10-29(18-22(33)34)11-13-31(20-24(36)39-27(4,5)6)15-17-32(16-14-30)21-25(37)40-28(7,8)9/h10-21H2,1-9H3,(H,33,34)
• Clé InChI: RVUXZXMKYMSWOM-UHFFFAOYSA-N

Description

Description générale

The most convenient reagent for the labeling of a peptide with DOTA ^[1]. This reagent has good solubility in DMF and DCM, and its free carboxyl group can be easily activated using uronium or phosphonium coupling reagents, enabling it to be attached to peptide amino groups. Removal of the t-butyl ester groups from the DOTA occurs during the course of the TFA-mediated cleavage reaction. The progress of the reaction should be monitored as the cleavage of these esters is slow, owing to the proximity of the basic ring nitrogens.

Literature references

^[1] L. M. De León-Rodrýguez & Z. Kovacs (2008) Bioconjugate Chem, 19, 391.

Remarque sur l'analyse

Colour (visual): white to grey
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (NMR): ≥ 95.0 %
Identity (NMR): passes test
NMR-spectrum: passes test

Informations légales

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°C): Not applicable